PMID: 8606868Sep 1, 1995Paper

Apoptotic bodies in prostatic intraepithelial neoplasia and prostatic adenocarcinoma following total androgen ablation

Pathology, Research and Practice
R MontironiG Fabris

Abstract

The frequency and location of apoptotic bodies (AB) were evaluated in hematoxylin- and eosin-stained sections of 12 radical prostatectomies from patients with prostatic adenocarcinoma pre-treated for 3 months with total androgen ablation. Results were compared with an untreated age-, morphology- and stage-matched control group. Treated prostates showed involutional changes, with cytoplasmic vacuolization and chromatin changes ranging from mild to severe condensation, similar to that observed in apoptosis. In treated benign prostatic epithelium, the mean number of AB was 1.64% (standard error (SE), 0.19%), 6.3 times greater than in the untreated group (mean, 0.26%; SE, 0.03%). AB were more frequent in the basal cell layer than in the lumenal cell layer, whereas in the untreated group, AB were almost exclusively found in the basal cell layer. In treated prostatic intraepithelial neoplasia (PIN present in 10 cases), the mean number of AB was 1.74% (SE, 0.04%), which was 2.56 and 2.32 times greater than in untreated low grade PIN (mean, 0.68%; SE, 0.15%) and high grade PIN (mean, 0.75%; SE, 0.11%), respectively. In treated and untreated PIN, the number of AB was greatest in the basal cell layer, less in the intermediate cell layer ...Continue Reading

References

Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·R MontironiL Diamanti
Aug 1, 1994·Histopathology·S Nawaz, R H Fennell

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Citations

Aug 1, 1996·The Prostate·D G BostwickA Lopez-Beltran
Jul 13, 2002·The Journal of Pathology·C S FosterY Ke
Jan 1, 1997·Virchows Archiv : an International Journal of Pathology·R MontironiD G Bostwick
Jun 29, 2004·Der Pathologe·B Helpap, J Köllermann
Mar 1, 1997·The American Journal of Surgical Pathology·V E GouldD G Bostwick
May 13, 1998·Journal of Clinical Pathology·R Montironi, C C Schulman
Oct 18, 2014·Future Oncology·Roberta MazzucchelliRodolfo Montironi
Jun 2, 2004·International Journal of Cancer. Journal International Du Cancer·Jin-Rong ZhouGeorge L Blackburn
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Jan 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David G Bostwick, Junqi Qian
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·C S FosterW A Sakr
May 23, 2007·Archives of Pathology & Laboratory Medicine·David G Bostwick, Isabelle Meiers
Jan 13, 2000·American Journal of Rhinology·N MirzaK T Montone
May 13, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Bernard Têtu

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