Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor.

Mediators of Inflammation
André Luis Lacerda BachiMiriam G Jasiulionis

Abstract

There is evidence that the platelet-activating factor receptor (PAFR) is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype. Our group has previously shown that coinjection of a large number of apoptotic cells can promote tumor growth from a subtumorigenic dose of melanoma cells. Here, we studied the involvement of the PAFR in the tumor growth promoting effect of apoptotic cells. A sub-tumorigenic dose of melanoma cells (Tm1) was coinjected with apoptotic Tm1 cells, subcutaneously in the flank of C57Bl/6 mice, and the volume was monitored for 30 days. Animals received the PAFR antagonists, WEB2170 or PCA4248 (5 mg/kg body weight) or vehicle, by peritumoral daily injection for 5 days. Results showed that PAFR antagonists significantly inhibited the tumor growth induced by the coinjection of a sub-tumorigenic dose of melanoma cells together with apoptotic cells. This was accompanied by inhibition of early neutrophil and macrophage infiltration. Addition of (platelet-activating factor) to this system has no significant effect. PAFR antagonists did not affect the promoting effect of carrageenan. We suggest that the recognition of apoptotic cells by phagocytes le...Continue Reading

References

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Citations

Oct 15, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Marianna M KogaSonia Jancar
Oct 10, 2015·FEBS Letters·Renata de Freitas SaitoRoger Chammas
Jul 23, 2014·The Journal of Investigative Dermatology·Matheus FerraciniJeffrey B Travers
Aug 12, 2014·BioMed Research International·Jiamin ZhouJi Ming Wang
Jan 31, 2014·The Journal of Biological Chemistry·Johanna RiveraDavid L Goldman
Apr 3, 2020·Cellular & Molecular Immunology·Mieke MetzemaekersPaul Proost
Mar 10, 2016·Oncotarget·Ravi P SahuJeffrey B Travers
Sep 19, 2019·Nutrition & Metabolism·Cesar Miguel Momesso Dos SantosRenata Gorjão
Feb 21, 2018·Frontiers in Oncology·Ildefonso Alves da Silva-JuniorSonia Jancar

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