PMID: 16633167Apr 25, 2006Paper

Apoptotic changes of Middle East jaw lymphoma

The Journal of Craniofacial Surgery
Raja Kummoona, Aliaa Maky

Abstract

Jaw lymphoma a highly malignant tumor affects children between two and eight years, duration of illness between two and three weeks, and the general condition of severe toxicity, and the death rate is 91.9%. The aim of this cellular study is to show the apoptotic changes associated with these tumors. Twenty-four children, 13 boys and 11 girls, were reported with jaw lymphoma and studied for apoptotic detection of the tumor through morphological assessment by using ground section and electron microscopy. Ground section shows lymphoblastic lymphoma, darkly-stained of ribonucleic acid, also apoptotic changes seen in some of the cells. Electron microscopy showed high mitotic figures, lymphoblast transformed to plasma cell, high nucleocytoplasmic ratio, some cells showed double nuclei, some nuclei are crested in shape or convoluted, degenerative changes seen in some of the cells, chromatin clumps near the nuclear membrane, mitochondria showing homogenous and degenerative changes, virus like particles seen in this nucleus and cytoplasm. The presence of low-level of apoptosis is a poor prognostic feature of jaw lymphoma due to homogeneity and degenerative changes of the mitochondria and disruption of the cell surface.

References

Mar 5, 1999·Cellular and Molecular Life Sciences : CMLS·R R Wallace-Brodeur, S W Lowe
Nov 14, 2000·The American Journal of Pathology·J C Reed
Jun 23, 2001·BMJ : British Medical Journal·C Haslett, J Savill
Jun 23, 2001·BMJ : British Medical Journal·J Sjöström, J Bergh

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Citations

Nov 13, 2007·The Journal of Craniofacial Surgery·Raja Kummoona
Aug 13, 2008·Ultrastructural Pathology·Raja KummoonaDhamia Kareem Al-Rahal
Feb 6, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Raja KummoonaHeader Al-Muala
Dec 22, 2007·Ultrastructural Pathology·Raja Kummoona
Jan 24, 2009·The Journal of Craniofacial Surgery·Raja Kummoona

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