Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Fangyuan NieXiaofeng Ma

Abstract

Breast cancer is one of the most common cancers and is the second leading cause of cancer mortality in women worldwide. Novel therapies and chemo-therapeutic drugs are urgently needed to be developed for the treatment of breast cancer. Increasing evidence suggests that fatty acid synthase (FAS) plays an important role in breast cancer, for the expression of FAS is significantly higher in human breast cancer cells than in normal cells. Tannic acid (TA), a natural polyphenol, possesses significant biological functions, including bacteriostasis, hemostasis, and anti-oxidant. Our previous studies demonstrated that TA is a natural FAS inhibitor whose inhibitory activity is stronger than that of classical FAS inhibitors, such as C75 and cerulenin. This study further assessed the effect and therapeutic potential of TA on FAS over-expressed breast cancer cells, and as a result, TA had been proven to possess the functions of inhibiting intracellular FAS activity, down-regulating FAS expression in human breast cancer MDA-MB-231 and MCF-7 cells, and inducing cancer cell apoptosis. Since high-expressed FAS is recognized as a molecular marker for breast cancer and plays an important role in cancer prognosis, these findings suggest that TA i...Continue Reading

References

Apr 27, 2000·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H SakagamiT Yoshida
Feb 17, 2001·Biochemical and Biophysical Research Communications·I AbeH Noguchi
Nov 9, 2001·Biochemical and Biophysical Research Communications·X Wang, W Tian
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Johannes V SwinnenGuido Verhoeven
Mar 28, 2006·Biochemical Pharmacology·Bharat B Aggarwal, Shishir Shishodia
Jun 17, 2006·Cancer Research·Francis P Kuhajda
Jan 2, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Kristin R Landis-PiwowarQ Ping Dou
Jun 5, 2007·Current Opinion in Oncology·Johanna Bendell, Richard M Goldberg
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph R CarverUNKNOWN ASCO Cancer Survivorship Expert Panel
Sep 14, 2007·Chemico-biological Interactions·K S Sebastian, Raghava Varman Thampan
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hajime OritaEdward Gabrielson
Sep 3, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kim WalterMichael Goggins
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward
Dec 27, 2013·International Journal of Breast Cancer·Brian W BoothKaren J L Burg

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Citations

Feb 5, 2016·Journal of Cellular Physiology·William B KinlawNancy B Kuemmerle
Apr 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jessica Nayelli Sánchez-CarranzaLeticia González-Maya
Jan 10, 2017·PloS One·Yirong SunHaihong Wang
Apr 29, 2018·Scientific Reports·Krungchanuchat SaowalakPilapong Chalermchai
Mar 14, 2019·Journal of Analytical Methods in Chemistry·Zhaofeng Fu, Rui Chen
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rana A YounessMohamed A Farag
Apr 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhenhu GuoLingyun Zhao
Jun 17, 2021·Journal of Agricultural and Food Chemistry·Asifa KhanMohammad Askandar Iqbal

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