Apoptotic pathways in pemphigus.

Dermatology Research and Practice
Meryem BektasDavid S Rubenstein

Abstract

Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis. We review the current literature examining the role of apoptosis in pemphigus. Current data suggest that apoptosis is not required for blister induction, but that activation of proapoptotic proteins, including caspase cysteine proteinases, may sensitize cells to the acantholytic effects of pemphigus IgG.

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Citations

Mar 16, 2011·Autoimmune Diseases·Deyanira Pacheco-TovarEsperanza Avalos-Díaz
Feb 14, 2014·The Journal of Dermatological Treatment·Spyridoula DoukakiMaria Rita Bongiorno
Feb 11, 2012·Experimental Dermatology·María P GilMaría J López-Zabalza
Jun 25, 2021·Expert Review of Clinical Immunology·Ali NiliMaryam Daneshpazhooh
Aug 27, 2021·Frontiers in Medicine·Thomas Schmitt, Jens Waschke

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Methods Mentioned

BETA
biopsies
electrophoresis

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