PMID: 7022188Aug 1, 1981Paper

Apparent activation of 2-acetylaminofluorene and some aromatic amines by cytosolic preparations

Mutation Research
R ForsterJ W Gorrod

Abstract

The results presented here confirm that 2-acetylaminofluorene (AAF) can be activated to a mutagen by S105 rat liver post-microsomal fraction. The activity is Aroclor-inducible. It appears partly NADPH-independent, but on repeated centrifugation the NADPH independence is lost though the NADPH-dependent activation is retained. S105 activation is obtained whether the fraction is prepared with 0.15 M KCl or 0.25 M sucrose. Increasing amounts of S105 give increasing activation, with no evidence of an optimum. Activation by S105 is reduced in the presence of excess S9 and is inhibited by norharman. Under the same conditions, S105 produces mutagenic metabolites of 2-aminofluorene and 2-aminoanthracene but not ethidium bromide, dimethylaminoazobenzene or benzo(alpha)pyrene.

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K UmezawaT Sugimura
Nov 1, 1977·Nucleic Acids Research·K HayashiT Sugimura
Feb 1, 1976·Mutation Research·M H GreenB A Bridges
Sep 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P JennerA H Beckett

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Citations

Dec 1, 1983·Mutation Research·C E Phillipson, C Ioannides
Jan 29, 2003·Environmental and Molecular Mutagenesis·Manuel José Rodríguez-OrtegaJuan López-Barea
Jan 1, 1991·Environmental and Molecular Mutagenesis·M Matsumoto, M Ando
Jul 1, 1982·Mutation Research·D B McGregorR D Prentice

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