Apparent and internal validity of a Monte Carlo-Markov model for cardiovascular disease in a cohort follow-up study

Medical Decision Making : an International Journal of the Society for Medical Decision Making
Rogier L NijhuisM G Myriam Hunink

Abstract

To determine the apparent and internal validity of the Rotterdam Ischemic heart disease & Stroke Computer (RISC) model, a Monte Carlo-Markov model, designed to evaluate the impact of cardiovascular disease (CVD) risk factors and their modification on life expectancy (LE) and cardiovascular disease-free LE (DFLE) in a general population (hereinafter, these will be referred to together as (DF)LE). The model is based on data from the Rotterdam Study, a cohort follow-up study of 6871 subjects aged 55 years and older who visited the research center for risk factor assessment at baseline (1990-1993) and completed a follow-up visit 7 years later (original cohort). The transition probabilities and risk factor trends used in the RISC model were based on data from 3501 subjects (the study cohort). To validate the RISC model, the number of simulated CVD events during 7 years' follow-up were compared with the observed number of events in the study cohort and the original cohort, respectively, and simulated (DF)LEs were compared with the (DF)LEs calculated from multistate life tables. Both in the study cohort and in the original cohort, the simulated distribution of CVD events was consistent with the observed number of events (CVD deaths: 7...Continue Reading

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Citations

May 12, 2017·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Ankur PandyaThomas A Gaziano
Jan 4, 2017·Expert Review of Pharmacoeconomics & Outcomes Research·Issa J DahabrehThomas A Trikalinos
Mar 2, 2010·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Bas Groot KoerkampM G Myriam Hunink
Oct 27, 2010·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Bas Groot KoerkampM G Myriam Hunink
Apr 5, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Bob J H van KempenM G Myriam Hunink

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