Apparent diffusion coefficient-dependent voxelwise computed diffusion-weighted imaging: An approach for improving SNR and reducing T2 shine-through effects

Journal of Magnetic Resonance Imaging : JMRI
Sergios GatidisNina F Schwenzer

Abstract

To introduce and evaluate a method for signal-to-noise ratio (SNR) improvement and T2 shine-through effect reduction in diffusion-weighted magnetic resonance imaging (DWI). The proposed method uses quantitative information given by the voxel apparent diffusion coefficient (ADC) to derive voxelwise-computed DWI (vcDWI). Behavior of signal intensity variations was simulated and correlated with measurements using a dedicated phantom for DWI allowing for independent adjustment of T2 -relaxivity and diffusivity. Signal-to-noise (SNR) and contrast-to-noise (CNR) ratios were measured and compared to the method of computed DWI (cDWI). Image signal was correlated with ADCs to appreciate the extent of T2 shine-through effects. Additionally, the proposed method was retrospectively applied to whole-body DWI data of 20 patients with metastatic malignancies. vcDWI was compared to cDWI and measured DWI with respect to image quality, lesion detectability, and lesion diffusivity assessment. Theoretically predicted signal intensity variations showed a high correlation with measured phantom data (r > 0.96). The proposed method yielded lower background signal intensity variation and higher contrast (+144%) and CNR (+358%) for diffusion-restricted ...Continue Reading

References

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Oct 15, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sergios GatidisNina F Schwenzer
Jun 30, 2015·Journal of Magnetic Resonance Imaging : JMRI·Andrew B RosenkrantzDenis Le Bihan

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Citations

Mar 18, 2016·Radiological Physics and Technology·Yuto KonishiMasafumi Harada
Jul 12, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Toru HigakiKazuo Awai
Oct 18, 2018·Journal of Magnetic Resonance Imaging : JMRI·Jiejie ZhouMeihao Wang
Dec 7, 2018·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Koji YamashitaHiroshi Honda
Jul 11, 2019·The British Journal of Radiology·Qingyuan ChengMeihao Wang
Jul 10, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Bo Hwa ChoiEun Jung Jung

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