Apparent diffusion coefficient: potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases

Radiology
Yong CuiLin Shen

Abstract

To evaluate the ability of the apparent diffusion coefficient (ADC) to help predict response to chemotherapy in patients with colorectal and gastric hepatic metastases. Institutional review board approval was obtained; all patients provided informed consent. Standard magnetic resonance (MR) imaging and diffusion-weighted (DW) MR imaging were performed before and 3, 7, and 42 days after initiating chemotherapy for 87 hepatic metastases in 23 colorectal and gastric cancer patients (16 men, seven women; mean age, 55.7 years; range, 33-71 years). Lesions were classified as either responding or nonresponding, according to changes in size at the end of therapy. Linear mixed-effects modeling was applied to analyze change in ADCs and size following treatment. The Pearson correlation test was calculated between those ADC parameters and tumor response. Thirty-eight responding and 49 nonresponding metastatic lesions were evaluated. Pretherapy mean ADCs in responding lesions were significantly lower than those of nonresponding lesions (P = .003). An early increase in ADCs (on day 3 or 7) was observed in responding lesions but not in nonresponding lesions (P = .002). Weak but significant correlations were found between final tumor size redu...Continue Reading

References

May 1, 1992·Stroke; a Journal of Cerebral Circulation·H BenvenisteG A Johnson
Mar 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C C SchagP A Ganz
Sep 1, 1993·AJR. American Journal of Roentgenology·G D Dodd
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H LyngE K Rofstad
Dec 21, 2000·Journal of the National Cancer Institute·T L ChenevertB D Ross
Feb 27, 2001·BMJ : British Medical Journal·I J Beckingham, J E Krige
May 4, 2002·Neoplasia : an International Journal for Oncology Research·Dominique JenningsRobert J Gillies
Jul 31, 2002·Lancet·Andrzej Dzik-JuraszSimon Doran
Feb 22, 2003·European Journal of Radiology·Andreas M HernethMark Bednarski
Aug 23, 2003·AJR. American Journal of Roentgenology·Ihab R KamelJean-Francois Geschwind
Oct 27, 2004·Journal of Magnetic Resonance Imaging : JMRI·Harriet C ThoenyRobert Hermans
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel E HallBrian D Ross
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Rebecca J TheilmannAlison Stopeck
Mar 18, 2006·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Shinji NaganawaTakeo Ishigaki
Apr 4, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C Y Hao, J F Ji
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anna D WagnerWolfgang E Fleig
Jun 24, 2006·The British Journal of Radiology·D-M Koh, A R Padhani
Jul 27, 2006·Journal of Vascular and Interventional Radiology : JVIR·Jie DengAndrew C Larson
Aug 19, 2006·Magnetic Resonance Imaging·Martin D PicklesLindsay W Turnbull
Sep 27, 2006·Journal of the American College of Surgeons·Steven A EarleLeonidas G Koniaris
Mar 23, 2007·AJR. American Journal of Roentgenology·Dow-Mu KohJanet E Husband

❮ Previous
Next ❯

Citations

May 28, 2009·Abdominal Imaging·Melanie Bruegel, Ernst J Rummeny
Sep 7, 2013·Abdominal Imaging·Nyree Griffin, Vicky Goh
Aug 9, 2011·European Radiology·Doenja M J LambregtsRegina G H Beets-Tan
Apr 14, 2010·Nature Reviews. Clinical Oncology·Stavroula KyriaziNandita M deSouza
May 5, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·G S PatelT Ng
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jennifer PascalVittorio Cristini
Oct 1, 2010·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·P Murphy, D-M Koh
Oct 1, 2010·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·A AfaqD M Koh
Apr 12, 2013·BMC Medicine·Shaista Hafeez, Robert Huddart
Sep 23, 2009·AJR. American Journal of Roentgenology·Christina SchramlMarius Horger
Jun 23, 2010·AJR. American Journal of Roentgenology·Roberto Garcia FigueirasCarmen Villalba Martin
Jun 28, 2011·AJR. American Journal of Roentgenology·Ying-Shi SunXiao-Peng Zhang
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·R Adam SmithH Charles Manning
Apr 1, 2010·World Journal of Gastroenterology : WJG·Petra G Kele, Eric J van der Jagt
Jul 2, 2010·World Journal of Gastroenterology : WJG·Johnathan C ChungReed A Omary
Feb 3, 2011·World Journal of Radiology·Huaijun WangYicheng Ni
Apr 17, 2013·World Journal of Urology·Margarita BraunagelMike Notohamiprodjo
Dec 25, 2009·Radiology·Bachir Taouli, Dow-Mu Koh
Mar 17, 2009·Future Oncology·Christina Messiou, Nandita M deSouza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.