Apparent Diffusion Coefficient Value Changes and Clinical Correlation in 90 Cases of Cytomegalovirus-Infected Fetuses with Unremarkable Fetal MRI Results.

AJNR. American Journal of Neuroradiology
D KotovichGal Yaniv

Abstract

Cytomegalovirus is the leading intrauterine infection. Fetal MR imaging is an accepted tool for fetal brain evaluation, yet it still lacks the ability to accurately predict the extent of the neurodevelopmental impairment, especially in fetal MR imaging scans with unremarkable findings. Our hypothesis was that intrauterine cytomegalovirus infection causes diffusional changes in fetal brains and that those changes may correlate with the severity of neurodevelopmental deficiencies. A retrospective analysis was performed on 90 fetal MR imaging scans of cytomegalovirus-infected fetuses with unremarkable results and compared with a matched gestational age control group of 68 fetal head MR imaging scans. ADC values were measured and averaged in the frontal, parietal, occipital, and temporal lobes; basal ganglia; thalamus; and pons. For neurocognitive assessment, the Vineland Adaptive Behavior Scales, Second Edition (VABS-II) was used on 58 children in the cytomegalovirus-infected group. ADC values were reduced for the cytomegalovirus-infected fetuses in most brain areas studied. The VABS-II showed no trend for the major domains or the composite score of the VABS-II for the cytomegalovirus-infected children compared with the healthy po...Continue Reading

References

Jun 1, 1985·Journal of Pediatric Psychology·S S Sparrow, D V Cicchetti
Jan 2, 2001·Journal of Developmental and Behavioral Pediatrics : JDBP·R O TempleT J Boll
Nov 27, 2002·Journal of Magnetic Resonance Imaging : JMRI·Steven P MillerA James Barkovich
Feb 27, 2004·Current Neurology and Neuroscience Reports·Andrea Gropman
Jan 3, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Karen B Fowler, Suresh B Boppana
Apr 4, 2006·Reproductive Toxicology·Asher Ornoy, Orna Diav-Citrin
Sep 12, 2006·Seminars in Fetal & Neonatal Medicine·Petra S Hüppi, Jessica Dubois
Apr 4, 2007·European Radiology·J F SchneiderN Girard
Jun 21, 2007·Reviews in Medical Virology·Aileen Kenneson, Michael J Cannon
Oct 9, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Xin-Wen ZhangJian-Ping Zhang
Nov 11, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G BenoistY Ville
Dec 6, 2008·Neurologic Clinics·Ahmed N Abdelhalim, Ronald A Alberico
Jun 27, 2009·AJNR. American Journal of Neuroradiology·M M SchneiderO A Glenn
Aug 11, 2010·Journal of Autism and Developmental Disorders·Corey E Ray-SubramanianSusan Ellis Weismer
Nov 9, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Kathleen R FinkSumit Pruthi
Mar 12, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gregory A LodygenskyJeffrey J Neil
Aug 11, 2011·Infectious Disorders Drug Targets·Sean P Elliott
Jan 22, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claire L TownsendCatherine S Peckham
Jan 18, 2014·The Journal of Pediatrics·A Mackenzie DreherShannon A Ross
Apr 22, 2014·Neuroradiology·Chen HoffmannAnat Biegon
Oct 29, 2014·Pediatrics·Julie GoderisIngeborg Dhooge
Nov 22, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G YanivA Biegon
Sep 24, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Zin W NaingWilliam D Rawlinson

❮ Previous
Next ❯

Citations

Jan 13, 2019·Journal of Magnetic Resonance Imaging : JMRI·Alexandra M KorostyshevskayaVasily L Yarnykh
Jun 20, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Nadja SchönbergNedelina Slavova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.