Apparent exhaustion of the variable antigen repertoires of Trypanosoma vivax in infected cattle.

Infection and Immunity
V M NantulyaS K Moloo

Abstract

Three groups of cattle, each group comprising six animals, were inoculated intravenously with populations of bloodstream forms of Trypanosoma vivax. The first group received T. vivax clone ILDat 1.3 derived from an isolate from Nigeria, while the other two received T. vivax stocks IL 1875 or IL 2133 isolated from Coast Province, Kenya. One animal from the group that was infected with IL 1875 died 8 weeks postinfection. The remaining 17 animals became aparasitemic in 8 to 12 weeks without intervention by drug therapy. The recovered animals developed serodeme-specific immunity against Glossina morsitans subsp. centralis-transmitted challenge. There was complete cross-protection between the two East African T. vivax stocks, although they were isolated from areas 80 to 90 km apart, indicating that they belong to the same serodeme. Antibodies to the homologous metacyclic variable antigen types (VATs) were not detected in sera from recovered animals, suggesting that the immunity displayed by the recovered animals was directed at the bloodstream and not the metacyclic VATs. It is thus suggested that recovery in these animals is due to exhaustion of the repertoire of bloodstream VATs expressed in the animals by the infecting T. vivax c...Continue Reading

References

Jun 1, 1977·Experimental Parasitology·A CapbernP Mattern
Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·M MurrayW I McIntyre
Jan 1, 1977·Advances in Experimental Medicine and Biology·J J Doyle
Oct 1, 1976·International Journal for Parasitology·P LeeflangC Blotkamp
Aug 1, 1984·Parasitology·J D Barry, H Gathuo
May 1, 1983·Tropical Animal Health and Production·B T WelldeE A Opiyo

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Citations

Mar 1, 1993·The Journal of Eukaryotic Microbiology·M F DirieP R Gardiner
Feb 14, 2020·Nature Communications·Sara Silva PereiraAndrew P Jackson
Feb 1, 1997·Experimental Parasitology·R A MasakeV M Nantulya

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