PMID: 915297Jan 1, 1977

Apparent improvement of antisera for radioimmunoassay by treatment with sodium iodide

Journal of Immunological Methods
P SkrabanekD Powell

Abstract

The concept that antisera for radioimmunoassay can be improved by treatment with NaI and dialysis is challenged. Some antisera are little affected by NaI. Even when NaI does dissociate endogenous antigenic material from crude antiserum, in the subsequent dialysis NaI is dialysed at a much faster rate than antigen, allowing reassociation to occur. The reported improvement of antisera by the NaI method cannot be attributed to the effect of NaI but can be explained by the dilution which occurs during dialysis.

References

Mar 6, 1975·Nature·F Fyhrquist, M Wallenius
Dec 1, 1976·Irish Journal of Medical Science·R O'ConnellD Powell

Citations

Jan 1, 1980·Journal of Immunological Methods·R K HindawiD Riad-Fahmy
Mar 11, 1983·Journal of Immunological Methods·R Grønholt, J J Holst
Feb 1, 1994·Scandinavian Journal of Gastroenterology·J F Rehfeld
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Tiago MestreCristina Sampaio
Oct 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·V Kruse

Related Concepts

Immune complex
Physical Dialysis
Goat
Cavia porcellus
Immune Sera
Iodides
Polypeptides
Radioimmunoassay

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