Apparent microRNA-Target-specific Histone Modification in Mammalian Spermatogenesis

Evolutionary Bioinformatics Online
Y-H Taguchi

Abstract

Epigenetics is an important mRNA expression regulator. However, how distinct epigenetic factors, such as microRNAs (miRNAs) and promoter methylation, cooperatively regulate mRNA expression is rarely discussed. Recently, apparent miRNA regulation of promoter methylation was identified by bioinformatic analysis; however, it has not yet been experimentally confirmed. If miRNA regulation of other epigenetic factors were identified, it would reveal another layer of epigenetic regulation. In this paper, histone modifications (H3K4me1, H3K4me3, H3K27me3, H3K27ac, H3K9ac, and H2AZ) during mammalian spermatogenesis were studied and the apparent miRNA-target-specific histone modification was investigated by bioinformatic analyses of publicly available datasets. We identified several miRNAs' target genes that are significantly associated with histone modification during mammalian spermatogenesis. MiRNAs that target genes associated with the most significant histone modifications are expressed before or during spermatogenesis; thus the results were convincing. In this paper, we identified apparent miRNA regulation of histone modifications using a bioinformatics approach. The biological mechanisms of this effect should be further experiment...Continue Reading

References

Aug 20, 2004·European Journal of Biochemistry·Jérôme GovinSaadi Khochbin
Mar 27, 2007·Cold Spring Harbor Symposia on Quantitative Biology·M Zofall, S I S Grewal
Jul 21, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Naihong YanYongxin Ma
Aug 30, 2008·Molecular and Cellular Biology·Alicia Barroso-delJesusPablo Menendez
Sep 19, 2008·Genome Biology·Yong ZhangX Shirley Liu
Mar 25, 2009·Nature Reviews. Genetics·Howard Cedar, Yehudit Bergman
Apr 14, 2009·Nature Biotechnology·Robert L JudsonRobert Blelloch
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jul 17, 2010·Yonsei Medical Journal·Alfons Navarro, Mariano Monzo
Sep 22, 2010·RNA·Margaret S Ebert, Phillip A Sharp
Feb 18, 2011·Endocrinology·Peter K NichollsPeter G Stanton
Jul 12, 2011·Physiological Reviews·Danish Sayed, Maha Abdellatif
Dec 31, 2011·Journal of Molecular Evolution·Mercedita J Madison-Villar, Pawel Michalak
Jan 17, 2012·Current Opinion in Genetics & Development·Francisca E Reyes-Turcu, Shiv Is Grewal
Jan 25, 2012·International Journal of Molecular Sciences·Masato YoshizawaJun Yasuda
Feb 15, 2012·BMC Research Notes·Adam KiezunNoam Shomron
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
May 29, 2013·International Journal of Molecular Sciences·Yoshiro NagataKumiko Ui-Tei
Jan 1, 2014·Molecular Cell·Ruby YuDanesh Moazed
Mar 8, 2014·Genome Research·Christopher L BakerKenneth Paigen

❮ Previous
Next ❯

Citations

Jul 13, 2017·Antioxidants & Redox Signaling·Nihay Laham-KaramSeppo Ylä-Herttuala

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE49621
GSE57095
GSM392714
GSE52628
GSE56281

Software Mentioned

lars
miRviewer
samtools
dump
TargetScan
bowtie2
R
MiRaGE
UPGMA
fastq

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Research
Pål SaetromJohn J Rossi
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
Yuki Takada, Haruhiko Koseki
Current Opinion in Investigational Drugs
Muller Fabbri
Journal of Experimental & Clinical Cancer Research : CR
Xiaolan LiuYa Cao
© 2021 Meta ULC. All rights reserved