Apparent Treatment-resistant Hypertension Among Individuals with History of Stroke or Transient Ischemic Attack

The American Journal of Medicine
Virginia J HowardPaul M Muntner

Abstract

Blood pressure control is a paramount goal in secondary stroke prevention; however, high prevalence of uncontrolled blood pressure and use of multiple antihypertensive medication classes in stroke patients suggest this goal is not being met. We determined the prevalence and factors associated with apparent treatment-resistant hypertension in persons with/without stroke or transient ischemic attack. Data came from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a national, population-based cohort of 30,239 black and white adults aged ≥45 years, enrolled 2003-2007, restricted to 11,719 participants with treated hypertension. Apparent treatment-resistant hypertension was defined as (1) uncontrolled blood pressure (systolic ≥140 mm Hg or diastolic ≥90 mm Hg) with ≥3 antihypertensive medication classes, or (2) use of ≥4 antihypertensive medication classes, regardless of blood pressure level. Poisson regression was used to calculate characteristics associated with apparent treatment-resistant hypertension. Among hypertensive participants, prevalence of apparent treatment-resistant hypertension was 24.9% (422 of 1694) and 17.0% (1708 of 10,025) in individuals with and without history of stroke or transient...Continue Reading

References

Jul 1, 1995·Stroke; a Journal of Cerebral Circulation·D J Lanska, L H Kuller
May 1, 1997·Stroke; a Journal of Cerebral Circulation·G HowardV J Howard
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·T EngstadM Viitanen
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Mikael S MouradianAshfaq Shuaib
Jan 15, 2003·Neurology·S RulandUNKNOWN AAASPS Investigators. African American Antiplatelet Stroke Prevention Study
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Parveen RashidPhilip Bath
Jul 2, 2005·Neuroepidemiology·Virginia J HowardGeorge Howard
Mar 31, 2007·Stroke; a Journal of Cerebral Circulation·Deborah A LevineJeroan J Allison
Dec 12, 2007·Archives of Internal Medicine·Nathan D WongStanley S Franklin
May 1, 2009·Journal of Hypertension·Manoj KesarwaniStanley S Franklin
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 22, 2009·International Archives of Medicine·Shaheen E Lakhan, Michael T Sapko
Apr 9, 2010·Journal of the American Society of Hypertension : JASH·Virginia J HowardDaniel T Lackland
May 18, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·David A BrennerVirginia J Howard
Jun 23, 2011·Circulation. Cardiovascular Quality and Outcomes·Christianne L RoumieDawn M Bravata
Sep 9, 2011·Neurology·C D BushnellUNKNOWN AVAIL Investigators
May 26, 2012·Stroke; a Journal of Cerebral Circulation·Daniel T LacklandUNKNOWN Council on Quality of Care and Outcomes Research
Oct 4, 2012·The Journal of Clinical Hypertension·Marguerite R IrvinPaul Muntner
May 9, 2013·Circulation. Cardiovascular Quality and Outcomes·Nilay S ShahDonald M Lloyd-Jones
Jun 27, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J F Meschia
Jul 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Rikki M TannerPaul Muntner
Dec 21, 2013·The Permanente Journal·Kari L OlsonJohn A Merenich
Mar 29, 2014·Stroke; a Journal of Cerebral Circulation·Amytis TowfighiBruce Ovbiagele
Apr 1, 2014·The American Journal of Medicine·Sripal BangaloreUNKNOWN Get With the Guidelines-Stroke Steering Committee and Investigators
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Oct 31, 2014·Stroke; a Journal of Cerebral Circulation·James F MeschiaUNKNOWN Council on Hypertension

❮ Previous
Next ❯

Citations

Nov 25, 2014·Seminars in Nephrology·Jay I Lakkis, Matthew R Weir
Jun 22, 2017·Circulation·Gabriel S TajeuPaul Muntner
Jan 27, 2017·Journal of Human Hypertension·A J ShallcrossT M Spruill
Oct 26, 2018·Hypertension·Robert M CareyUNKNOWN American Heart Association Professional/Public Education and Publications Committee of the Council on Hypertension; Council
Oct 24, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fred Stephen Sarfo, Bruce Ovbiagele

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.