PMID: 9420026Jan 7, 1998Paper

Appearance of a metronidazole-resistant Helicobacter pylori strain in an infected-ICR-mouse model and difference in eradication of metronidazole-resistant and -sensitive strains

Antimicrobial Agents and Chemotherapy
S MatsumotoM Karita

Abstract

We tested whether antibiotic-resistant strains appeared in vivo after the failure of treatment using the Helicobacter pylori-infected euthymic mouse model. The numbers of colonies isolated from 56 ICR mice 2 weeks after 4 days of treatment with metronidazole (3.2, 10, or 32 mg/kg of body weight) or amoxicillin (1, 3.2 or 10 mg/kg), with treatment started 4 days after H. pylori CPY2052 inoculation, were counted, and the isolated strains were tested for their sensitivities to two antibiotics to rule out the presence of antibiotic-resistant strains. One metronidazole-resistant strain was detected in a mouse treated with 10 mg of metronidazole per kg, and the MIC of metronidazole for this strain was 25 microg/ml, compared to a MIC of 1.56 microg/ml for the original strain. However, no resistant strain was detected in the amoxicillin treatment group. After the examination described above, mice challenged with a metronidazole-resistant or -sensitive strain isolated from the stomach of a mouse were treated with metronidazole or amoxicillin. The metronidazole-resistant strain was more difficult to eradicate in vivo than the sensitive strain after treatment with metronidazole but not after treatment with amoxicillin. Thus, a metronidazo...Continue Reading

References

Feb 1, 1979·Antimicrobial Agents and Chemotherapy·J G Meingassner, J Thurner
Jan 1, 1992·Antimicrobial Agents and Chemotherapy·H RautelinT U Kosunen
Nov 16, 1991·Lancet·R P LoganJ H Baron
Mar 3, 1990·Lancet·M C BecxR W de Koning
Apr 21, 1990·Lancet·Y GlupczynskiD De Vos
Sep 1, 1990·Antimicrobial Agents and Chemotherapy·C E HaasJ J Schentag
Feb 1, 1989·Gastroenterology·D Y Graham
Oct 16, 1989·The Medical Journal of Australia·T J BorodyL L George
Jan 1, 1995·Alimentary Pharmacology & Therapeutics·G N Tytgat
Feb 1, 1994·Antimicrobial Agents and Chemotherapy·A A van ZwetJ A Snijder
Mar 1, 1993·Infection and Immunity·R ShutoM Nasu
Jan 1, 1993·The Journal of Antimicrobial Chemotherapy·D I Edwards
Feb 1, 1993·The Journal of Antimicrobial Chemotherapy·D I Edwards
Apr 1, 1996·The Journal of Antimicrobial Chemotherapy·A F Goddard, R P Logan
May 1, 1997·Journal of Medical Microbiology·S MatsumotoM Karita
May 1, 1993·Parasitology Today·P J Johnson

❮ Previous
Next ❯

Citations

Jul 11, 2009·Phytotherapy Research : PTR·Péter MolnárMasami Kawase
Apr 7, 2011·Phytotherapy Research : PTR·Hyung-In MoonJai-Heon Lee
May 20, 2003·Helicobacter·Tomoyuki OhnoJirO Imanishi
Oct 12, 2001·Journal of Gastroenterology and Hepatology·J YakoobZ Zhang
Jul 2, 1999·Antimicrobial Agents and Chemotherapy·K MabeT Takahashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.