PMID: 8458801Feb 1, 1993Paper

Appearance of airway absorption and exudation tracers in guinea pig tracheobronchial lymph nodes

Journal of Applied Physiology
Ingrid ErjefaltC G Persson

Abstract

This study examines the fate of extravasated plasma in inflammatory stimulus-challenged large tracheobronchial airways of ketamine-xylazine-anesthetized guinea pigs. Entry of plasma tracers into the airway lumen was determined by a validated noninjurious airway lavage technique. Removal by airway lymphatics was assessed by tracheobronchial lymph node levels of plasma tracers. Mucosal challenges with histamine (5 nmol), bradykinin (5 nmol), capsaicin (0.4 nmol), or allergen (ovalbumin, 3 pmol) increased the appearance of a plasma tracer (131I-labeled albumin previously injected intravenously) in the airway lumen within 10 min (10-20 times control; P < 0.001), whereas the contractile agent carbachol (8 nmol) was without exudative effect. The mediators were without effect, and capsaicin and allergen only slightly increased the lymph node level of plasma exudation tracer (1.5 times control; P < 0.05). Hence, removal via the lymphatic route of plasma macromolecules may be negligible in the acute and postacute phases of an airway exudation response. Experiments were also carried out with luminally applied macromolecular tracers. These were absorbed from the mucosal surface into the circulation, but a small portion was also transporte...Continue Reading

Citations

May 1, 1993·Clinical Physiology·L GreiffC G Persson
Oct 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C SvenssonC G Persson
Jun 1, 1993·Thorax·L GreiffC G Persson
Dec 8, 1998·Journal of Applied Physiology·E M WagnerW Mitzner
Feb 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J S ErjefältC G Persson
Sep 18, 1997·Journal of Applied Physiology·E M Wagner
Sep 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C G PerssonB Gustafsson
Jun 15, 2010·Respiratory Research·Carl G Persson, Lena Uller
Feb 2, 2021·Scandinavian Journal of Immunology·Carl Persson
Apr 16, 2021·Journal of Leukocyte Biology·E Evonne JeanDe'Broski R Herbert
Mar 24, 2020·Journal of Innate Immunity·Carl Persson

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