Appearance of breast cysts in planar geometry photoacoustic mammography using 1064-nm excitation

Journal of Biomedical Optics
M HeijblomSrirang Manohar

Abstract

In the search for improved imaging modalities for detection and diagnosis of breast cancer, a high negative prediction value is also important. Photoacoustic (optoacoustic) imaging is a relatively new technique that has high potential for visualizing breast malignancies, but little is known about the photoacoustic appearance of benign lesions. In this work, we investigate the visibility of benign breast cysts in forward-mode photoacoustic mammography using 1064-nm light, as currently applied in the Twente photoacoustic mammoscope. Results from (Monte Carlo and k-wave) simulations and phantom measurements were used to interpret results from patient measurements. There was a strong agreement among the results from simulations, phantom, and patient measurements. Depending on the absorption contrast between cyst and breast tissue, cysts were visible as either one or two confined high-contrast areas representing the front and the back of the cyst, respectively. This edge enhancement is most likely the consequence of the local sudden change in the absorbed energy density and Grüneisen coefficients. Although the current forward-mode single-wavelength photoacoustic mammoscope cannot always unambiguously discriminate cysts from malignan...Continue Reading

Citations

Nov 11, 2014·IEEE Photonics Journal·Junjie Yao, Lihong V Wang
May 15, 2015·IEEE Pulse·Michelle HeijblomSrirang Manohar
Apr 19, 2016·Journal of Biomedical Optics·Yong ZhouLihong V Wang

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