PMID: 6164654Jan 1, 1981Paper

Appearance of dextrans and antidextran antibodies in human sera

International Archives of Allergy and Applied Immunology
T Palosuo, F Milgrom

Abstract

The serologically active moiety of an antigen detected occasionally in pathologic sera by double-diffusion gel precipitation tests, referred to in earlier studies as ubiquitous tissue antigen, was identified as a dextran composed predominantly, if not exclusively, of a(1 leads to 6)-linked glycopyranoses. By means of an enzyme immunoassay, dextran or dextran-like material, which inhibited the binding of antidextran serum to dextran, was detected in sera of several patients with various gastrointestinal (GI) diseases, especially GI ulcers (7/10), and also often in sera of aged people (9/21). However, 2 of 50 normal blood donor sera and a few sera from almost every disease group studied contained low quantities of dextran-like material. The levels of antidextran antibodies of the IgG class were also often elevated among patients with GI diseases and aged people as demonstrated by enzyme immunoassay with dextran T-500 as the solid phase antigen. OD values exceeding the mean plus 2.5 SD of 106 normal blood donor sera were recorded in ;69% of patients with gastric and duodenal ulcers, 40% with ulcerative colitis, 29% with Crohn's disease, 20% with colorectal carcinomas, and in 21% with rheumatoid arthritis. None of 23 children, but ...Continue Reading

Citations

May 1, 1982·The Journal of Clinical Investigation·D K HendersonM A Huber
Jan 1, 1983·Scandinavian Journal of Rheumatology·C Tagesson, A Bengtsson
Aug 1, 1989·Baillière's Clinical Rheumatology·K D Katz, D Hollander
Sep 1, 1986·Tubercle·A H van Assendelft, A Jukkara
May 1, 1982·Immunology Today·A W Richter, H I Hedin
Jan 1, 1984·Immunological Communications·T MoritoF Milgrom
Jul 1, 1984·The Journal of Infection·G Keren, M Wolman

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