PMID: 7028762Oct 1, 1981Paper

Appearance of functional insulin receptors during the differentiation of embryonal carcinoma cells

The Journal of Cell Biology
J K HeathA R Rees

Abstract

The insulin-receptor binding activity and insulin-stimulated growth response of PC13 clone 5 cells were investigated for both the embryo carcinoma (EC) and retinoic acid-induced differentiated derivatives of this cell line. Whereas the EC cell was found to have very few, if any, receptors and showed no demonstrable dependence on insulin for growth, the differentiated derivative cell expressed a large number of insulin receptors and, when challenged with the hormone, showed stimulation of both DNA synthesis and cell division. The same data were obtained for five independent PC13 clones. These results, coupled with previous observations, lend weight to the suggestion that the appearance of specific receptors for growth regulatory substances may be a manifestation of a general change in growth-regulatory mechanisms accompanying EC cell differentiation and loss of malignancy.

References

Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A Rizzino, G Sato
Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R W Hollwy, J A Kiernan

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Citations

Jan 1, 1987·Cell and Tissue Research·B E HaskellJ R Perez-Polo
Mar 1, 1989·Environmental Health Perspectives·T SejersenN R Ringertz
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·E M McDowellL M De Luca
Mar 23, 2002·The American Journal of the Medical Sciences·K GuptaA N Peiris
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·D J Hill, J Hogg
Oct 1, 1986·Journal of the American Academy of Dermatology·F Chytil
Jun 1, 1983·Journal of Cellular Physiology·J K Heath, M J Deller
Dec 1, 1983·Journal of Cellular Physiology·C M Isacke, M J Deller
May 1, 1986·Journal of Cellular Physiology·A BaroffioP Kucera
Jan 1, 1987·Differentiation; Research in Biological Diversity·F SchulzeP Gruss
Jan 1, 1985·Differentiation; Research in Biological Diversity·G CossuL Warren
Jun 15, 1982·Biochemical and Biophysical Research Communications·L Nagarajan, W B Anderson
Mar 1, 1984·The Journal of Pathology·M MiettinenI Virtanen
Aug 3, 1988·Biochimica Et Biophysica Acta·P W Andrews

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