Appearance of glutamate-like immunoreactivity during retinal regeneration in the adult newt

Brain Research
Chikafumi Chiba

Abstract

The appearance of endogenous glutamate during retinal regeneration in the newt was examined by immunohistochemistry. Glutamate-like immunoreactivity (Glu-LI) first appeared in prospective ganglion cells along the vitreal margin of retinas that were about six cells thick, in prospective photoreceptors immediately before segregation of retinal plexiform layers and then in prospective bipolar cells immediately after the initial appearance of thin plexiform layers. In retinas nearing complete regeneration, Müller cells showed immunoreactivity. The appearance of glutamatergic phenotypes during retinal regeneration seemed to follow the order of cell differentiation [T. Saito, Y. Kaneko, F. Maruo, M. Niino, Y. Sakaki, Study of the regenerating newt retina by electrophysiology and immunohistochemistry (bipolar- and cone-specific antigen localization), J. Exp. Zool. 270 (1994) 491-500]. However, changes in the amount of endogenous glutamate during retinal regeneration were more complex. On the one hand, Glu-LI at the prospective ganglion cell layer temporarily increased during the initial period of segregation of the inner plexiform layer. On the other hand, immunoreactivity in the photoreceptor layer declined during segregation of the ...Continue Reading

References

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Citations

Jan 26, 2000·Development, Growth & Differentiation·Y KanekoY Hanyu
Jul 30, 2008·Experimental Eye Research·Kanako SusakiChikafumi Chiba
Feb 18, 2006·The Journal of Comparative Neurology·Chikafumi ChibaTakehiko Saito
Mar 29, 2002·The Journal of Comparative Neurology·Kouji YasuyamaFriedrich-Wilhelm Schürmann
Apr 20, 2004·Progress in Retinal and Eye Research·Peter HitchcockDeborah Otteson

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