Appearance of hepatobiliary diseases in a population-based cohort with inflammatory bowel diseases (Inflammatory Bowel Disease Cohort of the Uppsala Region)

Journal of Gastroenterology and Hepatology
Anders RönnblomDaniel Sjöberg

Abstract

To prospectively follow the evolution of hepatobiliary diseases in a population-based cohort of patients with inflammatory bowel diseases. Between 2005 and 2009, 790 incident cases of ulcerative colitis and Crohn's disease were registered in the Uppsala Health Region, corresponding to an average incidence of 20.0 and 9.9 new cases/100 000 inhabitants/year, respectively. Liver function tests were analyzed in 97.1% and the results of ensuing investigations were summarized. Seventeen patients with primary sclerosing cholangitis were diagnosed corresponding to an overall prevalence of 2.2% (ulcerative colitis 1.7% and Crohn's disease 3.0%, respectively). The median age at diagnosis was 25 years (interquartile range: 17.0-34.0). Among the 92 patients below 17 years of age, three had autoimmune hepatitis and three primary sclerosing cholangitis, summing up to a prevalence of 6.5% immune-mediated hepatobiliary diseases among the pediatric patients. Three patients have undergone liver transplantation and one died of colonic carcinoma. Ten patients have demonstrated persistent elevation of alkaline phosphatases but had a normal magnetic resonance cholangiopancreatography (two patients) or refused further investigation (one patient). In ...Continue Reading

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Citations

Jan 13, 2016·Journal of Pediatric Gastroenterology and Nutrition·Matteo BramuzzoUNKNOWN SIGENP IBD Group
Feb 12, 2020·European Journal of Gastroenterology & Hepatology·Katerina KaraivazoglouChristos Triantos
Jan 5, 2017·Gastroenterology Research and Practice·Carthage MoranFergus Shanahan
Oct 4, 2017·World Journal of Gastroenterology : WJG·Morten L HallingLars Koch Hansen
Apr 1, 2018·Journal of Leukocyte Biology·Maria LampinenMarie Carlson
May 24, 2021·Gastroenterología y hepatología·Henrique C Rocha, Eduardo G Vilela

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