Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis

Journal of Neuroscience Research
Tomomi SanagiKeiko Ohsawa

Abstract

Microglial activation occurs early during the pathogenesis of amyotrophic lateral sclerosis (ALS). Recent evidence indicates that the expression of mutant Cu(2+)/Zn(2+) superoxide dismutase 1 (SOD1) in microglia contributes to the late disease progression of ALS. However, the mechanism by which microglia influence the neurodegenerative process and disease progression in ALS remains unclear. In this study, we revealed that activated microglia aggregated in the lumbar spinal cord of presymptomatic mutant SOD1(H46R) transgenic rats, an animal model of familial ALS. The aggregated microglia expressed a marker of proliferating cell, Ki67, and phagocytic marker proteins ED1 and major histocompatibility complex (MHC) class II. The motoneurons near the microglial aggregates showed weak choline acetyltransferase (ChAT) immunoreactivity and contained reduced granular endoplasmic reticulum and altered nucleus electron microscopically. Furthermore, immunopositive signals for tumor necrosis factor-alpha (TNFalpha) and monocyte chemoattractant protein-1 (MCP-1) were localized in the aggregated microglia. These results suggest that the activated and aggregated microglia represent phagocytic features in response to early changes in motoneurons...Continue Reading

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Citations

Sep 1, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Renzo MancusoXavier Navarro
Jan 8, 2014·Molecular Neurobiology·Ruying FuYamei Tang
Jul 30, 2011·The Journal of Comparative Neurology·Nichole A MesnardKathryn J Jones
Aug 18, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Feng He, Rudi Balling
Sep 21, 2010·Molecular and Cellular Neurosciences·Laia TolosaJerònia Lladó
Jun 7, 2014·Frontiers in Cellular Neuroscience·Dora Brites, Ana R Vaz
Nov 23, 2018·Acta Neuropathologica·Madelyn E McCauley, Robert H Baloh
Jul 25, 2019·The Journal of Biological Chemistry·Kazuhiko NamekataTakayuki Harada

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