PMID: 4399414Nov 1, 1971Paper

Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone

Proceedings of the National Academy of Sciences of the United States of America
J F BachA White

Abstract

After incubation with thymosin, a thymic hormone, normal bone marrow rosette-forming cells acquire T-cell characteristics, including increased sensitivity to azathioprine, anti-lymphocyte serum, and anti-theta serum. This activity of thymosin provides a new sensitive and reproducible bioassay for thymosin, and is well correlated with an in vivo graft-versus-host assay. In addition, incubation of spleen cells from adult thymectomized mice with thymosin in vitro restores to normal their diminished sensitivity to azathioprine and anti-lymphocte serum.

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