PMID: 3320427Aug 1, 1987Paper

Appearance of tuberculoma during treatment of tuberculous meningitis

Japanese Journal of Medicine
A PauranikM C Maheshwari

Abstract

Case histories of two young Indian female patients are described who, during the course of regular chemotherapy for tuberculous meningitis, developed tuberculoma as suggested by CT-scan. Such lesions were not seen at the start of treatment. Twelve similar cases are collected from literature. Most of the patients developed new symptoms and/or signs having initially shown good response to drugs. The pathogenetic mechanisms for such an evolution of lesions are not known but possibly include immunological modulations. This development should not lead to excessive anxiety for treating physician. Surgery is not needed and a patient follow up is well rewarded. Pyrazinamide has emerged as a useful drug.

Citations

Nov 1, 1995·Indian Journal of Pediatrics·S KumarC Sharma
Feb 1, 1994·Clinical Neurology and Neurosurgery·S K LinY Y Wai
Nov 3, 2004·Pediatric Neurology·Ming-Han TsaiTzou-Yien Lin
Apr 11, 2008·Clinical Microbiology Reviews·R Bryan RockPhillip K Peterson
Nov 10, 2011·Journal of Pediatric Neurosciences·Sandip Chatterjee
Apr 23, 2004·Leukemia & Lymphoma·Arun S ShetMichael Belzer
Dec 1, 1994·Journal of Neurosurgery·M R GropperL Wolansky
May 5, 2020·Wellcome Open Research·Suzaan MaraisUNKNOWN Tuberculous Meningitis International Research Consortium
Jan 24, 2019·SAGE Open Medical Case Reports·Ira Shah, Naman S Shetty
Oct 2, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yuying LuDing Liu

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