Appendicitis in HIV-infected patients during the era of highly active antiretroviral therapy.

HIV Medicine
N Crum-CianfloneM Bavaro

Abstract

Limited studies have suggested increased incidence rates and unusual clinical presentations of appendicitis among HIV-infected patients during the pre-highly active antiretroviral therapy (HAART) era. Data in the HAART era are sparse, and no study has evaluated potential HIV-related risk factors for the development of appendicitis. We retrospectively studied 449 HIV-infected patients receiving care at a US Naval hospital involving 4750 person-years (PY) of follow-up. We also evaluated the rates of appendicitis among HIV-negative persons at our medical facility. We compared demographics, HIV-specific data, and HAART use in HIV-infected patients with and without appendicitis. Sixteen (3.6%) of 449 patients developed appendicitis after HIV seroconversion. The incidence rate was 337 cases/100 000 PY, more than fourfold higher than among HIV-negative persons. Eighty-eight per cent of cases among HIV-infected patients had an elevated white blood count at presentation, 39% were complicated, and 64% required hospitalization. HIV-infected patients with appendicitis compared with those who did not develop appendicitis were less likely to be receiving HAART (25 vs. 71%, P<0.001), had higher viral loads (3.5 vs. 1.7 log(10) HIV-1 RNA copie...Continue Reading

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Citations

Oct 12, 2010·Annals of African Medicine·Robert B Sanda
Apr 26, 2011·Emergency Medicine Clinics of North America·Amanda E Horn, Jacob W Ufberg
Aug 25, 2016·The American Journal of Medicine·Hao-Ming LiChia-Hung Kao
Feb 10, 2018·Open Forum Infectious Diseases·Mariane H SchleimannRajesh Mohey
Jun 13, 2019·World Journal of Surgery·Alemayehu Ginbo BedadaGeorges Azzie
Jun 3, 2017·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·S SobnachD Kahn
Jan 17, 2014·Internal Medicine·Hiroshi MoriokaKenji Ohnishi
Jul 6, 2018·The Indian Journal of Surgery·Ritesh GigabhoyBhugwan Singh
Feb 23, 2021·SAGE Open Medicine·Arshad MahmoodMohamed H Ahmed

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