In an analysis of the first 72 cases treated after the formulation of the appendicitis syndrome in 1886 compared with the experience from 1929-1959 and with 307 randomly selected recent cases, the major therapeutic trend has been an emphasis on appendectomy before perforation and abscess formation occur. The rate of infection nonetheless remains approximately 17%. Although the overall mortality rate has declined from 26% overall (40% for surgery) to 0.8%, the current rate of perforation is 28%, with a diagnostic accuracy of 82%. Among 13,848 patients from several reports the perforation rate increases linearly with diagnostic accuracy; therefore, a balance must be sought. Delay awaiting a diagnosis is a major determinant of perforation, but diagnostic aids are of limited help. Clinical acuity and prudent decisiveness are the keys to proper action.
An assessment of the value of the white cell count in the management of suspected acute appendicitis
Human and computer-aided diagnosis of abdominal pain: further report with emphasis on performance of clinicians
Effect of prophylactic antibiotics in acute nonperforated appendicitis: a prospective, randomized, double-blind clinical study
Understanding mental health treatment in persons without mental diagnoses: results from the National Comorbidity Survey Replication
Transient appendiceal enlargement in a patient with colonic amebiasis: sonographic detection and follow-up
Post-1950 mortality trends and medical care: gains in life expectancy due to declines in mortality from conditions amenable to medical intervention in The Netherlands
Is there a role for leukocyte and CRP measurements in the diagnosis of acute appendicitis in the elderly?
Diagnosis of appendicitis in adults by ultrasonography or computed tomography: a systematic review and meta-analysis
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 35-1990. A 28-year-old Guatemalan woman with recurrent abdominal pain, fever, and diarrhea
A prospective randomized comparison of laparoscopic appendectomy with open appendectomy: Clinical and economic analyses
Comparison of needlescopic appendectomy versus conventional laparoscopic appendectomy: a randomized controlled trial
False-negative and false-positive errors in abdominal pain evaluation: failure to diagnose acute appendicitis and unnecessary surgery
Routine versus selective abdominal computed tomography scan in the evaluation of right lower quadrant pain: a randomized controlled trial
The nonvisualized appendix: incidence of acute appendicitis when secondary inflammatory changes are absent
Right lower quadrant pain and suspected appendicitis: nonfocused appendiceal CT--review of 100 cases
Pregnant patients suspected of having acute appendicitis: effect of MR imaging on negative laparotomy rate and appendiceal perforation rate
Integrating MR imaging into the clinical workup of pregnant patients suspected of having appendicitis is associated with a lower negative laparotomy rate: single-institution study
Comparison of US and unenhanced multi-detector row CT in patients suspected of having acute appendicitis
Utility of ultrasound for evaluating the appendix during the second and third trimester of pregnancy
Laparoscopic appendectomy: differences between male and female patients with suspected acute appendicitis
Changing incidence of acute appendicitis and nonspecific abdominal pain between 1987 and 2007 in Finland
Delayed primary closure versus primary closure for wound management in perforated appendicitis: a prospective randomized controlled trial
Acute appendicitis: investigating an optimal outer appendiceal diameter cut-point in a pediatric population
Pitfalls and mimickers at 64-section helical CT that cause negative appendectomy: an analysis from 1057 appendectomies
The impact of helical computed tomography on the negative appendectomy rate: a multi-center comparison
Computed tomography-based clinical diagnostic pathway for acute appendicitis: prospective validation
Surgically avertable burden of digestive diseases at first-level hospitals in low and middle-income regions
Laparoscopic appendectomy: Which factors are predictors of conversion? A high-volume prospective cohort study
Helical CT imaging of clinically suspected appendicitis: correlation of CT and histological findings
Mandatory imaging cuts costs and reduces the rate of unnecessary surgeries in the diagnostic work-up of patients suspected of having appendicitis
The Role of Digital Rectal Examination for Diagnosis of Acute Appendicitis: A Systematic Review and Meta-Analysis
Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Systematic Review and Meta-analysis of Controlled Trials (PROSPERO 2015: CRD42015016882)
LOW-DOSE CT PROTOCOL OPTIMIZATION FOR THE ASSESSMENT OF ACUTE APPENDICITIS: THE OPTICAP PHANTOM STUDY
Effects of Timing of Appendectomy on the Risks of Perforation and Postoperative Complications of Acute Appendicitis
Comparison of perforation risk among physicians, other medical professionals and general adults with acute appendicitis in Taiwan
Appendicitis: the impact of computed tomography imaging on negative appendectomy and perforation rates
Variables in right iliac fossa anatomy and their relevance to appendicectomy: improving knowledge and practices
Prospective examination of patients suspected of having appendicitis using new computed tomography criteria including "maximum depth of intraluminal appendiceal fluid greater than 2.6 mm"
Global prevalence and incidence of surgical site infections after appendectomy: a systematic review and meta-analysis protocol
'To have...or not to have'. Should computed tomography and ultrasonography be implemented as a routine work-up for patients with suspected acute appendicitis in a regional hospital?
A comparative ultrasound and plain abdominal x-ray: Evaluation of non-classical clinical cases of appendicitis
Diagnostic Accuracy of Abdominal Ultrasound for Diagnosis of Acute Appendicitis: Systematic Review and Meta-analysis
Unexpected Appendiceal Pathologies and Preoperative Imaging Studies on Patients With Acute Appendicitis
Epidemiology and Risk Factors for Superficial Surgical Site Infections after Appendectomy for Acute Appendicitis: A Secondary Data Analysis.
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