PMID: 2501511Jun 1, 1989Paper

Appetite-modulating drugs in dwarf goats, with special emphasis on benzodiazepine-induced hyperphagia and its antagonism by flumazenil and RO 15-3505

Journal of Veterinary Pharmacology and Therapeutics
A S van MiertC T van Duin

Abstract

In dwarf goats fasted for 2 h, i.v. administration of the benzodiazepine (BZ) agonists diazepam (60 micrograms/kg), brotizolam (2 and 4 micrograms/kg) and climazolam (100 micrograms/kg) induced hyperphagic effects, whereas i.v. injections of the BZ-antagonist flumazenil (R degrees 15-1788; 0.5 mg/kg), the anthelmintic ivermectin (0.1 mg/kg), the 5-HT2 antagonist ritanserine (0.1 mg/kg), ACTH (10 micrograms/kg) and prednisolone (1 mg/kg) were inactive in a 30-min feeding test. Both the BZ-antagonist R degrees 15-3505 (greater than or equal to 0.1 mg/kg) and the opiate receptor antagonist naloxone (0.1 mg/kg) had anorectic effects in dwarf goats given 30 min access to a palatable pelleted concentrate. The hyperphagic effects of climazolam and brotizolam were not antagonized by flumazenil, whereas similar doses of this drug completely reversed muscle incoordination and ataxia induced by much higher doses of these BZ-agonists. In the combination experiments with naloxone and BZ-agonists, naloxone antagonized the hyperphagic effects of both diazepam and brotizolam. Similarly, in the diazepam-R degrees 15-3505 study, there was a significant effect of diazepam and a significant inhibition of this effect by R degrees 15-3505 (50 microg...Continue Reading

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Citations

Apr 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·F KayaA S Van Miert
Jun 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·J E IlkiwE P Steffey
May 1, 1992·Zentralblatt für Veterinärmedizin. Reihe A·T Nicholson, T E Osman
Mar 21, 1998·Journal of Veterinary Pharmacology and Therapeutics·A S van Miert, C T van Duin
Jul 29, 2021·Journal of Medical Primatology·Jessica Ann HerrodJessica Marie Izzi

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