Appetite regulation in Schizothorax prenanti by three CART genes

General and Comparative Endocrinology
Dengyue YuanZhiqiong Li

Abstract

In recent years, cocaine- and amphetamine-regulated transcript (CART) has received much attention as mediators of appetite regulation in mammals. However, the involvement of CART in the feeding behavior of teleosts has not been well understood. In this study, three distinct CARTs were cloned from the Schizothorax prenanti (S. prenanti). Real-time quantitative PCR were applied to characterize the tissue distribution and appetite regulatory effects of CARTs in S. prenanti. The S. prenanti CART-1, CART-2 and CART-3 full-length cDNA sequences were 597 bp, 694 bp and 749 bp in length, encoding the peptides of 125, 120 and 104 amino acid residues, respectively. All the S. prenanti CARTs consisted of three exons and two introns. Tissue distribution analysis showed that the high mRNA levels of S. prenanti CART-1 were observed in the telencephalon and eye, followed by the hypothalamus, myelencephalon, and mesencephalon. The S. prenanti CART-2 mRNA was mainly found in the mesencephalon, hypothalamus, telencephalon and myelencephalon. The S. prenanti CART-3 mRNA was widely distributed among the tissues, with the high levels in the hypothalamus and foregut. In the periprandial experiment, all three CARTs mRNA expressions in the hypothalamu...Continue Reading

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Citations

Jul 30, 2016·General and Comparative Endocrinology·Hélène VolkoffJosé Eurico Possebon Cyrino
Oct 28, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hélène VolkoffJosé Eurico Possebon Cyrino
Mar 5, 2020·Fish Physiology and Biochemistry·Dengyue YuanZhiqiong Li
Mar 16, 2019·Frontiers in Endocrinology·Juan Ignacio BertucciSuraj Unniappan

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