Abstract
In recent years, cocaine- and amphetamine-regulated transcript (CART) has received much attention as mediators of appetite regulation in mammals. However, the involvement of CART in the feeding behavior of teleosts has not been well understood. In this study, three distinct CARTs were cloned from the Schizothorax prenanti (S. prenanti). Real-time quantitative PCR were applied to characterize the tissue distribution and appetite regulatory effects of CARTs in S. prenanti. The S. prenanti CART-1, CART-2 and CART-3 full-length cDNA sequences were 597 bp, 694 bp and 749 bp in length, encoding the peptides of 125, 120 and 104 amino acid residues, respectively. All the S. prenanti CARTs consisted of three exons and two introns. Tissue distribution analysis showed that the high mRNA levels of S. prenanti CART-1 were observed in the telencephalon and eye, followed by the hypothalamus, myelencephalon, and mesencephalon. The S. prenanti CART-2 mRNA was mainly found in the mesencephalon, hypothalamus, telencephalon and myelencephalon. The S. prenanti CART-3 mRNA was widely distributed among the tissues, with the high levels in the hypothalamus and foregut. In the periprandial experiment, all three CARTs mRNA expressions in the hypothalamu...Continue Reading
References
Mar 9, 1996·Gene·J Douglass, S Daoud
May 1, 1997·Journal of Chemical Neuroanatomy·P R CouceyroM J Kuhar
Jul 14, 1998·Synapse·P D LambertM J Kuhar
Jan 30, 1999·The International Journal of Biochemistry & Cell Biology·L ThimB S Wulff
Dec 29, 1999·Brain Research·L D AdamsM J Kuhar
Apr 20, 2000·Regulatory Peptides·M J KuharY Smith
Sep 7, 2000·The Journal of Comparative Neurology·Y L Hurd, P Fagergren
Nov 20, 2001·Endocrinology·H Volkoff, R E Peter
Jul 31, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·J P H Wilding
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·Richard G Hunter, Michael J Kuhar
Oct 22, 2004·Nature·Olivier JaillonHugues Roest Crollius
Nov 16, 2004·Annals of the New York Academy of Sciences·Geraldina DominguezMichael J Kuhar
Aug 19, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Axel Meyer, Yves Van de Peer
Oct 8, 2005·Endocrinology·Csaba FeketeRonald M Lechan
Jun 10, 2006·Peptides·Philip J Larsen, Richard G Hunter
Jun 13, 2006·Peptides·Niels Vrang
Jul 11, 2006·Peptides·Ersin O KoyluSakire Pogun
Jan 27, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Amy S Kehoe, Hélène Volkoff
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guillaume de LartigueGraham J Dockray
May 29, 2008·Endocrine Journal·Sanghee SeoSeungjoon Park
Sep 20, 2008·Nature Reviews. Neuroscience·G RoggeM J Kuhar
Feb 20, 2009·Obesity·Natalie R Lenard, Hans-Rudolf Berthoud
Apr 1, 2009·General and Comparative Endocrinology·Koji MurashitaIvar Rønnestad
Apr 16, 2010·Pharmacological Reviews·Gary D LopaschukJagdip S Jaswal
Nov 17, 2010·General and Comparative Endocrinology·Koji Murashita, Tadahide Kurokawa
Mar 8, 2011·General and Comparative Endocrinology·R ValenI Rønnestad
Mar 1, 2012·General and Comparative Endocrinology·Brian C PetersonBrian C Small
Jun 16, 2012·Molecular Endocrinology·Shin-Ichi NishioVincent Laudet
Aug 1, 2012·Molecular Phylogenetics and Evolution·Jay F StorzFederico G Hoffmann
Jun 6, 2013·Endocrinology·Cadence TrueM Susan Smith
Jun 19, 2013·Gene·RongBin WeiZhiQiong Li
Jul 16, 2013·Regulatory Peptides·RongBin WeiZhiQiong Li
Sep 26, 2013·Gene·Rongbin WeiZhiqiong Li
Citations
Jul 30, 2016·General and Comparative Endocrinology·Hélène VolkoffJosé Eurico Possebon Cyrino
Oct 25, 2016·Peptides·Xin ZhangZhiqiong Li
Oct 28, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hélène VolkoffJosé Eurico Possebon Cyrino
Mar 5, 2020·Fish Physiology and Biochemistry·Dengyue YuanZhiqiong Li
May 20, 2019·Fish Physiology and Biochemistry·Chaowei ZhouZonglin Zheng
Nov 17, 2017·Fish Physiology and Biochemistry·Xin ZhangZhiqiong Li
Mar 16, 2019·Frontiers in Endocrinology·Juan Ignacio BertucciSuraj Unniappan
Jan 9, 2021·Fish Physiology and Biochemistry·Dengyue YuanLijun Li
Jul 3, 2021·Life·Daniel AssanGuangli Li