Appetitive changes during salt deprivation are paralleled by widespread neuronal adaptations in nucleus accumbens, lateral hypothalamus, and central amygdala.

Journal of Neurophysiology
Shashank TandonMiguel A L Nicolelis

Abstract

Salt appetite is a goal-directed behavior in which salt-deprived animals ingest high salt concentrations that they otherwise find aversive. Because forebrain areas such as the lateral hypothalamus (LH), central amygdala (CeA), and nucleus accumbens (NAc) are known to play an important role in this behavior, we recorded from these areas while water-deprived (WD) and salt-deprived (SD) rats performed a two-bottle choice test between 0.5 M salt (NaCl) and 0.4 M sucrose. In the SD state, the preference ratio for high molar salt markedly increased. Electrophysiological recordings analyzed with respect to the onset of licking clusters revealed the presence of both excitatory and inhibitory neuronal responses during salt and/or sucrose consumption. In the NAc, putative medium spiny neurons and tonically active neurons exhibited excitatory and inhibitory responses. In all areas, compared with those recorded during the WD state, neurons recorded during the SD state showed an increase in the percentage of salt-evoked excitatory responses and a decrease in the percentage of sucrose-evoked inhibitory responses, suggesting that a subset of the neuronal population in these areas codes for the increased motivational and/or hedonic value of th...Continue Reading

References

Mar 1, 1978·Brain Research Bulletin·J S Schwartzbaum, J R Morse
Jan 11, 1992·Brain Research Bulletin·O GalavernaA N Epstein
Dec 15, 1990·The Journal of Comparative Neurology·D S Zahm, L Heimer
Nov 1, 1988·Journal of Electron Microscopy Technique·C R Gerfen
Dec 1, 1988·The Journal of Physiology·K M JacobsT R Scott
Jun 30, 1970·Brain Research·R Norgren
Jan 1, 1967·The American Journal of Physiology·G Wolf, D Quartermain
Aug 1, 1984·Behavioral Neuroscience·J SchulkinJ W Ternes
Jan 1, 1984·Experimental Brain Research·S AzumaY Kawamura
Aug 1, 1984·Behavioral Neuroscience·K C BerridgeH J Grill
Sep 1, 1995·The American Journal of Physiology·K Nakamura, R Norgren
Nov 14, 1997·Journal of Neurophysiology·H Nishijo, R Norgren
Jun 11, 1999·The American Journal of Physiology·M F Roitman, I L Bernstein
Jul 23, 1999·Annals of the New York Academy of Sciences·D S Zahm
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S A McCaughey, T R Scott
Dec 20, 2000·Brain Research·L W Swanson
Jan 29, 2002·Methods : a Companion to Methods in Enzymology·J D KralikM A Nicolelis
Oct 18, 2002·Neuron·Clifford B SaperJoel K Elmquist
Apr 5, 2003·Physiology & Behavior·Robert F LundyRalph Norgren
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Jeremy J Clark, Ilene L Bernstein
Nov 26, 2004·Journal of Neurophysiology·Michael C WiestMiguel A L Nicolelis
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sharif A Taha, Howard L Fields
Aug 27, 2005·Journal of Neurophysiology·Ranier GutierrezS A Simon

❮ Previous
Next ❯

Citations

Jun 15, 2015·NeuroImage·Heleen R HoogeveenMonicque M Lorist
May 11, 2013·Current Biology : CB·Paul A S Breslin
May 14, 2016·Journal of Neurophysiology·Andrea L Gutman, Sharif A Taha
May 18, 2018·Bio-protocol·Stephen E Chang, Kyle S Smith
Apr 19, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M J McKinley
Sep 21, 2018·Frontiers in Psychiatry·Ted M HsuMitchell F Roitman
Nov 19, 2015·Frontiers in Behavioral Neuroscience·Marc A ParentMark Laubach
Dec 25, 2017··Stephen ChangKyle Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.