Appetitive Olfactory Learning and Long-Term Associative Memory in Caenorhabditis elegans

Frontiers in Behavioral Neuroscience
Saori Nishijima, Ichiro N Maruyama

Abstract

Because of the relative simplicity of its nervous system, Caenorhabditis elegans is a useful model organism to study learning and memory at cellular and molecular levels. For appetitive conditioning in C. elegans, food has exclusively been used as an unconditioned stimulus (US). It may be difficult to analyze neuronal circuits for associative memory since food is a multimodal combination of olfactory, gustatory, and mechanical stimuli. Here, we report classical appetitive conditioning and associative memory in C. elegans, using 1-nonanol as a conditioned stimulus (CS), and potassium chloride (KCl) as a US. Before conditioning, C. elegans innately avoided 1-nonanol, an aversive olfactory stimulus, and was attracted by KCl, an appetitive gustatory stimulus, on assay agar plates. Both massed training without an intertrial interval (ITI) and spaced training with a 10-min ITI induced significant levels of memory of association regarding the two chemicals. Memory induced by massed training decayed within 6 h, while that induced by spaced training was retained for more than 6 h. Animals treated with inhibitors of transcription or translation formed the memory induced by spaced training less efficiently than untreated animals, whereas ...Continue Reading

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Citations

Jul 18, 2019·Royal Society Open Science·Baptiste PiqueretPatrizia d'Ettorre
Mar 8, 2019·Frontiers in Molecular Neuroscience·Mario Rafael Pagani, Emiliano Merlo
Mar 10, 2021·Translational Neurodegeneration·Xiaobing Huang, Garry Wong
Jul 2, 2021·Biochemical and Biophysical Research Communications·Vishnu RajAnoopkumar Thekkuveettil

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