Apple juice intervention modulates expression of ARE-dependent genes in rat colon and liver.

European Journal of Nutrition
Bülent SoyalanChristine Janzowski

Abstract

The risk of cancer and other degenerative diseases is inversely correlated with consumption of fruits and vegetables. This beneficial effect is mainly attributed to secondary plant constituents such as polyphenols, supposed to play a major role in protection against ROS (reactive oxygen species)-associated toxicity. To elucidate the potential of differently manufactured apple juices (clear AJ/cloudy AJ/smoothie, in comparison with a polyphenol-free control juice) to modulate expression of ARE-dependent genes. In male Sprague-Dawley rats (n = 8/group; 10d juice intervention, 4d wash-out; 4 treatment cycles), expression of target genes (superoxide dismutase, SOD1/SOD2; glutathione peroxidase, GPX1/GPX2; γ-glutamylcysteine ligase, GCLC/GCLM; glutathione reductase, GSR; catalase, CAT; NAD(P)H:quinone oxidoreductase-1, NQO1 and transcription factor erythroid-derived 2-like-2, Nrf2) was quantified with duplex RT-PCR, using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as control. In colon and liver of rats consuming polyphenol-free control juice, rather similar basic expressions were observed (relative GAPDH ratios ranging from 2 to 0.7 and 2.5-0.3, respectively). In the distal colon, apple juice intervention slightly but signific...Continue Reading

References

Nov 10, 1995·Archives of Biochemistry and Biophysics·F F Chu, R S Esworthy
Aug 25, 1995·Nucleic Acids Research·S K Goda, N P Minton
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Oct 18, 2000·Free Radical Biology & Medicine·A K Jaiswal
May 14, 2004·Nutrition Journal·Jeanelle Boyer, Rui Hai Liu
Jan 11, 2005·The American Journal of Clinical Nutrition·Claudine ManachChristian Rémésy
Feb 12, 2005·Antioxidants & Redox Signaling·Makoto Kobayashi, Masayuki Yamamoto
Oct 19, 2005·FEBS Letters·Janice E DrewGarry G Duthie
Dec 1, 2005·Molecular Nutrition & Food Research·Sandra SchaeferChristine Janzowski
Feb 4, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jie ChenRunsheng Ruan
Aug 22, 2006·Biochemical Pharmacology·Irfan RahmanPaul A Kirkham
Mar 17, 2007·Journal of Agricultural and Food Chemistry·William MullenAlan Crozier
Apr 25, 2007·Nucleic Acids Research·Warren A Kibbe
Jun 15, 2007·Toxicologic Pathology·Lauren M Aleksunes, José E Manautou
Jan 29, 2008·Journal of Agricultural and Food Chemistry·Navindra P SeeramDavid Heber
May 17, 2006·Journal of Agricultural and Food Chemistry·Mathieu SilberbergChristine Morand
May 30, 2009·Reviews on Environmental Health·Wieslaw Jedrychowski, Umberto Maugeri
Sep 19, 2009·Molecular Nutrition & Food Research·Mathias JungGerhard Erkel

❮ Previous
Next ❯

Citations

May 21, 2013·International Journal of Food Sciences and Nutrition·Pilar Codoñer-FranchVictoria Valls-Bellés
Mar 5, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Shiao DingJu Mei
Oct 9, 2012·Phytotherapy Research : PTR·Małgorzata KujawskaJadwiga Jodynis-Liebert
Jun 11, 2015·Toxicology Mechanisms and Methods·Flávia Andressa Pidone RibeiroDaniel Araki Ribeiro
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Carolina Foot Gomes de MouraDaniel Araki Ribeiro
Oct 16, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Violetta Krajka-KuźniakWanda Baer-Dubowska
Feb 26, 2016·European Journal of Nutrition·Giuseppe GrossoAndrzej Pająk
Sep 7, 2011·Nature Reviews. Gastroenterology & Hepatology·Luigi RicciardielloVincenzo Fogliano
May 24, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sui PengStuart Jon Spechler
Dec 11, 2014·World Journal of Gastroenterology : WJG·Saravana Kumar JaganathanMustafa Yusof
May 25, 2021·Critical Reviews in Food Science and Nutrition·José João Caires Serina, Paula Cristina Machado Ferreira Castilho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.