Apple Supplementation Improves Hemodynamic Parameter and Attenuates Atherosclerosis in High-Fat Diet-Fed Apolipoprotein E-Knockout Mice

Biomedicines
Raffaella SoletiRamaroson Andriantsitohaina

Abstract

Epidemiological studies describe the association between apple consumption and improved cardiovascular and metabolic dysfunction. Our recent multiparametric screening on cellular model studies has shown that apples exhibit vascular tropism including Granny Smith (GS) variety independently of the storage condition. The present study aimed to evaluate the cardiovascular and metabolic protection of supplementation of GS variety after storage in classic cold (GSCC) and extreme ultra-low oxygen conditions (GSXO) in the apolipoprotein E-deficient 8-week-old mice fed with high fat diet for 14 weeks. Supplementation with GSCC and GXO decreases circulating triglycerides, the expression of genes involved in lipogenesis, without change in cholesterol and glucose concentrations and HOMA-IR. Only GSXO supplementation ameliorates body weight gain, insulin level, and HDL/LDL ratio. GSXO supplementation does not modify cardiac parameters; while supplementation with GSCC decreases heart rate and improves cardiac output. Interestingly, GSCC and GSXO reduce systolic and diastolic blood pressure with a differential time course of action. These effects are associated with substantial decrease of atherosclerotic lesions. These data reinforce the kno...Continue Reading

References

May 23, 2001·Journal of Agricultural and Food Chemistry·J B GoldingD N Leach
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M H MoghadasianJ J Frohlich
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Jeffrey B BoordGökhan S Hotamisligil
Mar 7, 2003·Nutrition·Maria Conceição de OliveiraAnibal Sanchez Moura
Feb 1, 1957·The American Journal of Physiology·M C SCHOTZI H PAGE
Jun 9, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Agnieszka Dobrzyn, James M Ntambi
Oct 4, 2006·Free Radical Research·Francisco Perez-VizcainoRamaroson Andriantsitohaina
Sep 28, 2007·Journal of Oleo Science·Yoko Nagasako-AkazomeTetsuyuki Kobayashi
Jun 19, 2008·Journal of Agricultural and Food Chemistry·Sylvain AuclairAugustin Scalbert
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elisa FabbriniSamuel Klein
Feb 26, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·David SánchezAmaya Aleixandre
Jul 27, 2011·Diabetes·Norbert Stefan, Hans-Ulrich Häring
Oct 14, 2011·American Journal of Hypertension·Lu WangHoward D Sesso
Feb 15, 2012·Advances in Nutrition·Abigail J LarsonThunder Jalili
Jul 24, 2012·Journal of the Academy of Nutrition and Dietetics·Sheau C ChaiBahram H Arjmandi
Dec 29, 2012·European Journal of Nutrition·Gitte Ravn-HarenSusanne Bügel
Jan 5, 2014·Circulation Research·Carlos Silvestre-RoigOliver Soehnlein
May 29, 2015·Nutrients·Athanasios KoutsosJulie A Lovegrove
Jun 16, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Jaime GonzalezRodrigo Moore-Carrasco
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Noura SamoutNajla Hfaiedh
Sep 25, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Charlotte TrenteseauxKhadija Ouguerram
Jun 18, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Maria ArconzoAntonio Moschetta

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
enzymatic assay
PCR

Software Mentioned

GraphPad Prism
GraphPad
Nanozoomer Digital Pathology View

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