Applicability of common inflammatory markers in diagnosing infections in early period after liver transplantation in intensive care setting.

Scientific Reports
Wojciech FigielKrzysztof Zieniewicz

Abstract

Infections remain an important cause of morbidity and mortality early after liver transplantation. The aim of this prospective longitudinal study was to evaluate clinical utility of c-reactive protein (CRP), procalcitonin, and neutrophil-to-lymphocyte ratio (NLR) in surveillance of infections early after liver transplantation in intensive care setting. A total of 60 liver transplant recipients were included. CRP, procalcitonin, and NLR assessed at 12-hour intervals were primary variables of interest. Infections and severe complications during postoperative intensive care unit stay were the primary and secondary end-points, respectively. Infections and severe complications were diagnosed in 9 and 17 patients, respectively. Only peak CRP beyond first 48 hours was associated with infections (p = 0.038) with AUC, positive and negative predictive value of 0.728, 42.9% and 92.2%, respectively (cut-off: 142.7 mg/L). Peak procalcitonin over first 60 hours was the earliest predictor (p = 0.050) of severe complications with AUC, positive and negative predictive value of 0.640, 53.3% and 80.0%, respectively (cut-off: 42.8 ng/mL). In conclusion, while CRP, procalcitonin, and NLR cannot be used for accurate diagnosis of infections immediate...Continue Reading

References

Jul 8, 2008·Critical Care : the Official Journal of the Critical Care Forum·Daniel EyraudLaurent Hannoun
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Frédéric BertMarie-Hélène Nicolas-Chanoine
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maartje A J van den BroekFuat H Saner
Aug 3, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kim M OlthoffJason D Christie
Sep 7, 2013·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Michał GrątMarek Krawczyk
Dec 18, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E BucheliUNKNOWN Swiss Transplant Cohort Study
Jan 5, 2014·Journal of Hepatology·Stefano FagiuoliUNKNOWN 2011 AISF Single Topic Group
Aug 27, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·T KaidoS Uemoto
May 21, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Anup ParikhBaburao Koneru
Jun 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tarek SawasWon Kyoo Cho
Jul 3, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marcus R PereiraElizabeth C Verna
Nov 4, 2015·Annals of Surgery·Valentina GiaccagliaGiovanni Ramacciato
Jan 30, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Asahi SatoShinji Uemoto
May 18, 2016·Archives of Medical Science : AMS·Aristotelis PerrakisVolker Müller
Oct 30, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Josh LevitskyAbraham Shaked
Oct 27, 2016·Medical Microbiology and Immunology·Angela ChiereghinTiziana Lazzarotto
Feb 9, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cybele Lara R AbadRaymund R Razonable
Feb 17, 2017·BMC Infectious Diseases·Vladimir L CousinValérie A McLin
May 17, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michał GrątMarek Krawczyk
Jul 25, 2017·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·A BroccaC Ronco
Sep 18, 2017·International Journal of Colorectal Disease·E Domínguez-ComesañaR Domínguez-Fernández

❮ Previous
Next ❯

Citations

Jul 20, 2020·Alimentary Pharmacology & Therapeutics·Christine BernsmeierMark J W McPhail
May 8, 2021·International Journal of Clinical Practice·Adem KoseYasar Bayindir

❮ Previous
Next ❯

Software Mentioned

STATISTICA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved