Applicability of endoscopic indices in the determination of disease activity in patients with ulcerative colitis

European Journal of Gastroenterology & Hepatology
Marcin KucharskiAgnieszka Dobrowolska

Abstract

The combination of clinical remission and mucosal healing represents a major goal of different treatment strategies for ulcerative colitis (UC). This study aimed to assess which of the endoscopic indices used to evaluate mucosal changes in UC are correlated with clinical indices currently used to determine disease activity, as well as which of the endoscopic indices are correlated with the Geboes Index used for histological evaluation. It also aimed to find correlations between the currently used clinical activity indices and the histological Geboes Index. A group of 49 patients with a confirmed diagnosis of UC and a group of 52 individuals without a diagnosis of gastrointestinal disease, who constituted the control group, were investigated. All patients were evaluated by colonoscopy, and the severity of mucosal changes was scored in terms of nine different endoscopic indices commonly used in both pharmacological trials and clinical practice. Evaluation was also carried out using clinical and histological indices. Endoscopic indices used for UC were then correlated with different clinical and histological indices to find the strongest correlations. A high correlation was demonstrated between three of the 11 evaluated clinical i...Continue Reading

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Citations

Dec 26, 2018·Journal of Medical Biochemistry·Muhammet Yener AkpinarErtugrul Kayacetin

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BETA
biopsies
biopsy

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Statistica
UCEIS

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