DOI: 10.1101/479246Nov 29, 2018Paper

Applicability of subcortical EEG metrics of synaptopathy to older listeners with impaired audiograms

BioRxiv : the Preprint Server for Biology
Markus Garrett, Sarah Verhulst


Emerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known whether electrophysiological metrics targeting synaptopathy in animals can be applied to a broad range of people, such as those with impaired audiograms. This study investigates the applicability of subcortical electrophysiological measures associated with synaptopathy such as auditory brainstem responses (ABRs) and envelope following responses (EFRs) in older participants with high-frequency sloping audiograms. This is important for the development of reliable and sensitive synaptopathy diagnostics in people with normal or impaired outer-hair-cell function. Broadband click-ABRs at different sound pressure levels and EFRs to amplitude-modulated stimuli were recorded, as well as relative EFR and ABR metrics which reduce individual factors such as head size and noise floor level. Most tested metrics showed significant differences between the groups and did not always follow the trends expected from synaptopathy. Audiometric hearing loss and age-related hearing related deficits interacted to affect the electrophysiological metrics and complicated their interpretation in terms of synaptopathy. This study cont...Continue Reading

Related Concepts

Cochlear Diseases
Gene Products, env
Sensorineural Hearing Loss (Disorder)
Hearing Tests
Physiological Aspects
Type 2 Vestibular Sensory Cell

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