PMID: 16524102Mar 10, 2006Paper

Application of 1-alkyl-3-methylimidazolium-based ionic liquids in separation of bioactive flavonoids by capillary zone electrophoresis

Journal of Separation Science
Mei-E Yue, Yan-Ping Shi

Abstract

Room-temperature ionic liquids (ILs) are liquids that are constituted entirely of ions and can provide a solvent environment quite unlike any other available at room temperature. They continue to attract considerable interest in the chemistry research community as they are good solvents for a wide range of both inorganic and organic materials. In this study, a CZE method has been established for resolving natural flavonoids, quercetin, kaempferol and isorhamnetin in the Chinese herbal extract from Hippophae rhamnoides and its medicinal preparation (Sindacon Tablet). In this method, 1-alkyl-3-methyl-imidazolium-based ILs are used as the additive, and the effects of the alkyl group, imidazolium counterion (anionic part), along with the concentration of IL are investigated and discussed. Baseline separation, high efficiencies and symmetrical peaks of the three flavonoids were obtained. The separation mechanism seems to be the hydrogen-bonding interaction between the imidazolium cations of IL and the flavonoids.

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Citations

Dec 25, 2010·Journal of Pharmaceutical and Biomedical Analysis·Roberto Gotti
Sep 27, 2016·Green Chemistry : an International Journal and Green Chemistry Resource : GC·Belinda SoaresMara G Freire
Dec 1, 2006·Electrophoresis·Peng LiYi Tao Wang
Jul 12, 2007·Journal of Separation Science·Shahab A Shamsi, Neil D Danielson
Dec 12, 2007·Journal of Separation Science·Constantine D Stalikas
Dec 29, 2007·Electrophoresis·Mercedes López-PastorMiguel Valcárcel
Apr 28, 2012·Electrophoresis·Acácio MendesAna Luísa Simplício
Dec 8, 2011·Electrophoresis·Heide R RabanesJoselito P Quirino
Mar 8, 2017·Critical Reviews in Analytical Chemistry·Imran AliHassan Y Aboul-Enein
Dec 7, 2016·Electrophoresis·Baljinder SinghAshok Kumar Malik
Jan 8, 2014·Electrophoresis·Elena Domínguez-VegaMaría Luisa Marina

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