PMID: 9661275Jul 14, 1998Paper

Application of a Finnish mutagenicity model to drinking waters in the U.S

Chemosphere
Kathleen M SchenckR M Clark

Abstract

Recent epidemiological studies conducted in Finland have reported a positive correlation between the mutagenicity of chlorinated drinking waters and certain human cancers. In these studies, past exposure to drinking water mutagenicity was assessed using a model developed by Vartiainen et al. [1] based on data collected in Finland. In this model, mutagenicity, as determined in the Ames assay, is a function of the total organic carbon (TOC) concentration of the water, chlorine dose, and to a minor extent, the concentration of ammonia. A study has been initiated to assess the applicability of this model to source waters and water treatment practices in the United States. Water samples were collected from three full-scale treatment plants and one pilot-scale plant. All the plants used chlorine exclusively for disinfection. One full-scale plant used ground water. Surface water sources were used by the other plants. TOC and ammonia concentrations were determined analytically and chlorine doses were obtained from the treatment plants. The water samples were concentrated by XAD resin adsorption for testing in the Ames assay. The observed levels of mutagenicity in the finished waters were 1.5 to 2-fold higher than those predicted using ...Continue Reading

References

Nov 1, 1988·Mutation Research·J R Meier
Jan 1, 1986·Mutation Research·T Vartiainen, A Liimatainen
May 29, 1985·Journal of Chromatography·A G Sweeney, A M Cheh
May 1, 1983·Mutation Research·D M Maron, B N Ames
Jul 1, 1995·Archives of Environmental Health·M KoivusaloJ J Jaakkola
Aug 1, 1994·American Journal of Public Health·K P Cantor
Apr 1, 1987·Environmental Science & Technology·H P RinghandD E Mitchell

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Citations

Jul 26, 2002·Chemosphere·T K NissinenT Vartiainen
Mar 23, 2000·Mutation Research·J H ParkY S Lee
Mar 10, 2009·Journal of Toxicology and Environmental Health. Part a·Glenn E RicePaul I Feder
Mar 10, 2009·Journal of Toxicology and Environmental Health. Part a·Kathleen M SchenckGlenn E Rice
Sep 8, 2004·Water Research·Silvano MonarcaMilena Villarini
Feb 7, 2007·Journal of Environmental Sciences (China)·Jin-long ZuoGui-bing Zhu
May 10, 2005·Environmental and Molecular Mutagenesis·Silvano MonarcaBianca Gustavino
Jun 16, 2010·Environmental Toxicology·Smiljana BritvićSandra Stepić
Aug 16, 2001·The Journal of Veterinary Medical Science·J H ParkY S Lee
Sep 27, 2005·Mutation Research·Claudia ZaniSilvano Monarca
Jul 26, 2006·Mutation Research·Licia GuzzellaCarlo Rossi

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