Application of a flexible polymer microECoG array to map functional coherence in schizophrenia model

MethodsX
F Z FedorZ Fekete

Abstract

Anatomically, connections form the fundamental brain network, functionally the different types of oscillatory electric activities are creating a temporarily connected fraction of the anatomical connectome generating an output to the motor system. Schizophrenia can be considered as a connectome disease, in which the sensory input generates a schizophrenia specific temporary connectome and the signal processing becomes diseased showing hallucinations and adverse behavioral reactions. In this work, flexible, 32-channel polymer microelectrode arrays fabricated by the authors are used to map the functional coherence on large cortical areas during physiological activities in a schizophrenia model in rats.-Fabrication of a flexible microECoG array is shown.-Protocol to use a flexible microECoG is demonstrated to characterize connectome diseases in rats.-Customized method to analyze the functional coherence between different cortical areas during visually evoked potential is detailed.-R-based implementation of the analysis method is presented.

References

Jul 1, 1982·Archives of General Psychiatry·N C Andreasen, S Olsen
Oct 18, 2001·Brain Research Bulletin·O Szabó-SalfayG Juhász
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Axel BeckerGisela Grecksch
Dec 15, 2005·Journal of Neuroscience Methods·Brian A HollenbergDavid M Rector
Dec 18, 2007·Biological Psychiatry·Kevin M SpencerRobert W McCarley
Apr 19, 2008·Journal of Neuroscience Methods·Chiping WuLiang Zhang
May 14, 2009·Journal of Neural Engineering·Birthe RubehnThomas Stieglitz
Nov 19, 2011·Neural Computation·Jan PotworowskiDaniel Wójcik
Apr 25, 2013·CNS Neuroscience & Therapeutics·Bernat KocsisMihaly Hajos
Dec 20, 2013·Journal of Neurophysiology·Antal BerényiGyörgy Buzsáki

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Methods Mentioned

BETA
polymer

Software Mentioned

Gamry Framework
R
Spike2
BrainAreaR
Echem Analyst

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