PMID: 2499287Feb 1, 1989Paper

Application of a method of material-energy balance for controlling the process of microbiological synthesis of riboxin

Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
A I ToĭtmanG I Kil'fin

Abstract

Possible control of riboxin biosynthesis on the basis of the information provided with the method of material-energy balance was studied. Correspondence of the cultivation conditions to the directed biosynthesis was established by comparing the experimental values of the respiration coefficient delta CO2/delta O2, the coefficient of constructive and energy metabolism conjugate Cc/e and the ratio of the consumed amounts of glucose and ammonium nitrogen delta S/delta NH4+ with the theoretical values of these parameters. The control principle included changing of the process operation parameters for providing cultivation conditions approximating the experimental values of Cc/e, delta CO2/delta O2 and delta S/delta NH4+ to their theoretical values. It was shown possible to control directed aerobic growth of the culture by changing the aeration conditions. A decrease in the initial aeration rate promoted more rapid transition of the microbial population to the exponential growth phase and provided for a certain period cultivation conditions corresponding to the conditions of conjugate metabolism. It was found that the respiration coefficient could be used not only as a parameter reflecting one of the forms of the cell physiological ...Continue Reading

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