Application of aerosol solvent extraction system (ASES) process for preparation of liposomes in a dry and reconstitutable form

International Journal of Pharmaceutics
Sarinnate KunastitchaiBernd W Müller

Abstract

The aerosol solvent extraction system (ASES) process was applied to prepare liposomes in a dry and reconstitutable form. Dry ASES microparticles containing miconazole (MCZ) as a model drug were prepared by an optimized ASES process with various compositions of spraying solution containing phosphatidylcholine, cholesterol, and Poloxamer 407. The influence of such compositions and the pH of hydration medium on the physico-chemical properties of the produced microparticles were investigated before and after hydration. At optimized conditions, partially crystalline, spherical, and nonporous microparticles associated in aggregates varying from a few microns to 40 microm were produced with the residual content of methylene chloride and methanol lower than 30 and 86 ppm, respectively. The percentage of drug recovered in the produced microparticles was increased with an increase of the drug concentration in the spraying solution. The entrapment efficiency of hydrated MCZ microparticles was improved by increasing the pH of the hydration medium.

References

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Citations

Jul 4, 2008·AAPS PharmSciTech·Louise A MeureFariba Dehghani
Nov 1, 2011·Journal of Microencapsulation·Fei XiaXinqiu Guo
Sep 1, 2007·Pharmaceutical Development and Technology·Sarinnate KunastitchaiBernd W Müller
Apr 15, 2010·Journal of Liposome Research·Ruthairat BenjakulNarong Sarisuta
May 7, 2015·Journal of Liposome Research·Michael E Wagner, Syed S H Rizvi
Jan 19, 2012·Expert Opinion on Drug Delivery·Ana Catarina LimaJoão F Mano
Feb 8, 2011·Expert Opinion on Drug Delivery·Pall Thor IngvarssonCamilla Foged
Oct 6, 2012·Pharmaceutical Development and Technology·Priti GirotraKalpana Nagpal
Sep 17, 2013·Nanoscale Research Letters·Islane Espírito SantoElaine Cabral-Albuquerque
Nov 10, 2009·International Journal of Pharmaceutics·Yuichi TozukaHirofumi Takeuchi
Aug 28, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Chau Chun BehNeil R Foster
Oct 11, 2016·Chemical Society Reviews·N GrimaldiN Ventosa
Jul 29, 2017·Advanced Healthcare Materials·Ranjith Kumar KankalaAi-Zheng Chen
Jan 1, 2021·Pharmaceutics·Birendra Chaurasiya, You-Yang Zhao
Feb 12, 2018·ACS Biomaterials Science & Engineering·Selya Amrani, Maryam Tabrizian

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