Application of ancillary studies in soft tissue cytology using a pattern-based approach

Cancer Cytopathology
Ivan Chebib, Vickie Y Jo

Abstract

The cytologic diagnosis of soft tissue neoplasms has undergone many advances due to the development of numerous useful immunohistochemical markers and molecular assays that target specific molecular alterations. Ancillary tests, when used in conjunction with clinical, radiologic, and cytomorphologic features, allow for more accurate classification and refinement of differential diagnoses of soft tissue neoplasms. Soft tissue tumors encompass a diverse group of tumors showing a wide range of cytomorphologies that can be broadly grouped as lipomatous, myxoid, spindled, pleomorphic, round cell, and epithelioid. This pattern-based classification enables the formation of appropriate differentials; however, entities that share these basic morphologic patterns may vary greatly in their clinical behavior. The breadth of soft tissue tumors that can be diagnosed on cytologic preparations continues to increase with identification of defining molecular alterations that can be detected by conventional means (eg, fluorescence in situ hybridization) or by immunohistochemical surrogates. Furthermore, the emergence of high-throughput molecular techniques (eg, next generation sequencing) has potential roles for additional discovery and diagnosti...Continue Reading

References

Oct 1, 1989·The American Journal of Surgical Pathology·F M EnzingerC Y Liang
Mar 1, 1995·Diagnostic Cytopathology·P E WakelyW J Frable
Jan 1, 1994·Diagnostic Cytopathology·N P CarawayR E Pollock
Mar 13, 1997·Oncogene·M PeterO Delattre
Mar 4, 1998·Diagnostic Cytopathology·R BakhosC V Reyes
Apr 16, 1998·American Journal of Clinical Pathology·L G DoddM Gottfried
Nov 13, 1998·Diagnostic Cytopathology·L J LayfieldR K Dodge
Jan 13, 1999·Diagnostic Cytopathology·E E MooneyL G Dodd
Jan 13, 1999·Diagnostic Cytopathology·S E Kilpatrick, W G Ward
Feb 10, 1999·Diagnostic Cytopathology·D Nemanqani, W A Mourad
Mar 31, 1999·Acta Cytologica·J A Jiménez-HeffernanJ M Viguer
May 13, 1999·Diagnostic Cytopathology·L G DoddR E McLendon
Jun 12, 1999·The American Journal of Surgical Pathology·J M Meis-KindblomL G Kindblom
Jul 2, 1999·Cytopathology : Official Journal of the British Society for Clinical Cytology·G H YuP K Gupta
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P GinsbergF G Barr
Oct 19, 2000·Virchows Archiv : an International Journal of Pathology·M MiettinenJ Lasota
Jun 8, 2001·Cancer·M M LemosH Willén
Jun 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M A FurlongJ C Fanburg-Smith
Aug 4, 2001·The American Journal of Pathology·J A BridgeS W Morris
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Poul H B SorensenFrederic G Barr
Aug 31, 2002·Diagnostic Cytopathology·Jerzy KlijanienkoPhilippe Vielh
Nov 1, 2002·The American Journal of Surgical Pathology·Manuela PelmusJean-Michel Coindre

❮ Previous
Next ❯

Citations

Jan 30, 2020·Cancer Cytopathology·Vickie Y Jo
Nov 11, 2020·Journal of the American Society of Cytopathology : JASC·Lester J LayfieldJerzy Klijanienko
May 26, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Yonca KanberManon Auger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.