Application of Artificial Neural Network for Prediction of Risk of Multiple Sclerosis Based on Single Nucleotide Polymorphism Genotypes.

Journal of Molecular Neuroscience : MN
Soudeh Ghafouri-FardHossein Mohammad-Rahimi

Abstract

The artificial neural network (ANN) is a sort of machine learning method which has been used in determination of risk of human disorders. In the current investigation, we have created an ANN and trained it based on the genetic data of 401 multiple sclerosis (MS) patients and 390 healthy subjects. Single nucleotide polymorphisms (SNPs) within ANRIL (rs1333045, rs1333048, rs4977574 and rs10757278), EVI5 (rs6680578, rs10735781 and rs11810217), ACE (rs4359 and rs1799752), MALAT1 (rs619586 and rs3200401), GAS5 (rs2067079 and rs6790), H19 (rs2839698 and rs217727), NINJ2 (rs11833579 and rs3809263), GRM7 (rs6782011 and rs779867), VLA4 (rs1143676), CBLB (rs12487066) and VEGFA (rs3025039 and rs2071559) had been genotyped in all individuals. We used "Keras" package for generation and training the ANN model. The k-folds cross-validation strategy was applied to confirm model generalization and overfit prevention. The locally interpretable model-agnostic explanation (LIME) was applied to explain model predictions at the data sample level. The TT genotype of the GAS5 rs2067079 had the most protective effect against MS, while the DD genotype of the ACE rs1799752 was the most prominent risk genotype. The accuracy, sensitivity and specificity va...Continue Reading

References

Oct 20, 2005·Journal of Bioscience and Bioengineering·Shuta TomidaHiroyuki Honda
Apr 11, 2008·Genes and Immunity·I A HoppenbrouwersR Q Hintzen
Apr 30, 2013·Ageing Research Reviews·Nuria GaratacheaAlejandro Lucia
May 8, 2013·Acta Ophthalmologica·Elena Garcia-MartinJavier Fernandez
Nov 3, 2015·Pediatric Research·Enzo GrossiFilippo Muratori
Sep 23, 2016·Journal of the Neurological Sciences·Mohammad Mahdi EftekharianReza Mirfakhraie
Jun 8, 2017·Experimental and Therapeutic Medicine·Wen-Juan HuangXia Zhang
Nov 17, 2017·Multiple Sclerosis and Related Disorders·Mehrdokht MazdehMir Davood Omrani
May 2, 2018·Journal of Molecular Neuroscience : MN·Maryam RezazadehSoudeh Ghafouri-Fard
Jun 9, 2018·Clinical & Translational Immunology·Chris Cotsapas, Mitja Mitrovic
Mar 2, 2019·Immunological Investigations·Mohammad Mahdi EftekharianMohammad Taheri
Jul 12, 2019·Metabolic Brain Disease·Rezvan NorooziSoudeh Ghafouri-Fard
Feb 15, 2020·Multiple Sclerosis and Related Disorders·Mohammad TaheriSoudeh Ghafouri-Fard

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Citations

Dec 15, 2020·Briefings in Bioinformatics·Ninon BurgosOlivier Colliot
Feb 8, 2021·Neurología : publicación oficial de la Sociedad Española de Neurología·M Vázquez-MarrufoG Izquierdo
May 1, 2021·International Journal of Molecular Sciences·Alazne Arrazola SastreJosé L Zugaza

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Methods Mentioned

BETA
genotyping

Software Mentioned

Keras
scikit
LIME
matplotlib
ANN
learn

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