Application of biomaterials for the repair and treatment of osteonecrosis of the femoral head

Regenerative Biomaterials
Dewei Zhao, Zhijie Ma

Abstract

Osteonecrosis of the femoral head (ONFH) is one of the most common causes of hip disability in young adults. However, its cause and pathogenesis remain unclear, and might be caused by a variety of factors. ONFH mainly occurs in young adults. If not treated, 70-80% of patients would progress into femoral head collapse in 3 years, and eventually require hip arthroplasty. Since these patients are younger and more physically active, multiple revision hip arthroplasty might be needed in their life. Repeated revision hip arthroplasty is difficult and risky, and has many complications, which inevitably affects the physical and mental health of patients. To delay the time of total hip arthroplasty for young adult patients with ONFH, biomaterials are used for its repair, which has a high clinical and social value for the retention of the patient's own hip function. At present, there are many types of biomaterials used in repairing the femoral head, there is no uniform standard of use and the clinical effects are different. In this review, the main biomaterials used in the repair of ONFH are summarized and analyzed, and the prospects are also described.

References

Mar 1, 1996·Clinical Orthopaedics and Related Research·M A MontA C Fairbank
Feb 1, 1996·The Journal of Bone and Joint Surgery. American Volume·T P Vail, J R Urbaniak
Oct 6, 1998·The Journal of Bone and Joint Surgery. American Volume·S P ScullyJ R Urbaniak
Apr 9, 2002·Clinical Orthopaedics and Related Research·Racquel Zapanta LeGeros
Aug 27, 2005·Biomaterials·Frank WitteHenning Windhagen
Oct 26, 2005·Biomaterials·Mark P StaigerGeorge Dias
Jan 6, 2006·Clinical Orthopaedics and Related Research·Dewei ZhaoXu Cui
Jan 21, 2006·Biomaterials·Garrett RyanDimitrios Panagiotis Apatsidis
Mar 4, 2008·The Journal of Bone and Joint Surgery. American Volume·Kwang Woo NamHee Joong Kim
May 16, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ruiying WangCao Yang
Jun 4, 2008·The Journal of Bone and Joint Surgery. American Volume·M TanzerD Karabasz
Oct 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Chun-Chieh ChenMel S Lee
Nov 10, 2009·Clinical Orthopaedics and Related Research·Dewei ZhaoFengde Tian
Aug 7, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bogdan DabrowskiKrzysztof J Kurzydlowski
Nov 6, 2010·Biomechanics and Modeling in Mechanobiology·André LutzThilo Floerkemeier
Dec 17, 2010·Clinical Reviews in Allergy & Immunology·Christian PowellM Eric Gershwin
Dec 16, 2011·Endocrine·Robert S Weinstein
Jun 2, 2012·World Journal of Orthopedics·Anjan P KaushikQuanjun Cui
May 29, 2014·Journal of Materials Science. Materials in Medicine·V CampanaG Logroscino
Dec 7, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jingsheng ShiSiqun Wang
Jan 8, 2016·International Orthopaedics·Xianzuo ZhangZhanjun Shi
Jun 3, 2016·Regenerative Biomaterials·Mitsuo NiinomiHua Li
Oct 9, 2016·Acta Biomaterialia·Brecht Van HoorewederJean-Pierre Kruth
Jan 17, 2017·Journal of Reconstructive Microsurgery·Cassandra A LighL Scott Levin
Mar 3, 2017·Journal of Materials Science. Materials in Medicine·Wei ZhuXisheng Weng
May 23, 2017·Biofabrication·Nicholas SearsElizabeth Cosgriff-Hernandez
Aug 30, 2017·Scandinavian Journal of Pain·Gillian Z HellerRoberta Chow
Feb 10, 2018·Regenerative Biomaterials·Zhurong TangXingdong Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
total hip arthroplasty
scanning electron microscopy
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.