Application of biomaterials to advance induced pluripotent stem cell research and therapy

The EMBO Journal
Zhixiang TongJeffrey M Karp

Abstract

Derived from any somatic cell type and possessing unlimited self-renewal and differentiation potential, induced pluripotent stem cells (iPSCs) are poised to revolutionize stem cell biology and regenerative medicine research, bringing unprecedented opportunities for treating debilitating human diseases. To overcome the limitations associated with safety, efficiency, and scalability of traditional iPSC derivation, expansion, and differentiation protocols, biomaterials have recently been considered. Beyond addressing these limitations, the integration of biomaterials with existing iPSC culture platforms could offer additional opportunities to better probe the biology and control the behavior of iPSCs or their progeny in vitro and in vivo. Herein, we discuss the impact of biomaterials on the iPSC field, from derivation to tissue regeneration and modeling. Although still exploratory, we envision the emerging combination of biomaterials and iPSCs will be critical in the successful application of iPSCs and their progeny for research and clinical translation.

References

Apr 1, 1985·Journal of Biomedical Materials Research·S C WoodwardC G Pitt
Nov 2, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S N BhatiaM Toner
Feb 24, 2001·Gastroenterology·Z M Younossi
Nov 2, 2001·Nature Biotechnology·T P RichardsonD J Mooney
Mar 12, 2003·Advanced Drug Delivery Reviews·Jayanth Panyam, Vinod Labhasetwar
May 31, 2003·Somatic Cell and Molecular Genetics·Douglas L MillerJames E Greenleaf
Oct 2, 2003·Nature Materials·Henning Sirringhaus
Nov 19, 2003·Nature Materials·Amy C Richards GraysonRobert Langer
Nov 25, 2003·Biology of Reproduction·M AmitJ Itskovitz-Eldor
Dec 19, 2003·Expert Opinion on Biological Therapy·Neelesh K Varde, Daniel W Pack
Jun 15, 2004·Nature Biotechnology·Daniel G AndersonRobert Langer
Mar 23, 2005·Nature Methods·Christopher J FlaimSangeeta N Bhatia
Jun 21, 2005·Journal of Cellular Physiology·Somen SahaSean P Palecek
Jul 9, 2005·Nature Biotechnology·Rakesh K JainDai Fukumura
Nov 12, 2005·Stem Cells·Mark E LevensteinJames A Thomson
Mar 1, 2006·International Journal of Pharmaceutics·D KloseJ Siepmann
Jun 20, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Francis F TukovPatricia E Ganey
Jul 1, 2006·Nature·David T Scadden
Jan 24, 2007·Journal of Biomedical Materials Research. Part a·Gaye CetinkayaAşkin Tümer
May 8, 2007·ACS Chemical Biology·Ratmir DerdaLaura L Kiessling
Jul 28, 2007·Current Opinion in Chemical Biology·Gregory H Underhill, Sangeeta N Bhatia
Aug 19, 2007·Current Opinion in Chemical Biology·Ying MeiDaniel Anderson
Aug 28, 2007·Journal of Pharmaceutical Sciences·Farahidah Mohamed, Christopher F van der Walle
Oct 12, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Neelesh K Varde, Daniel W Pack
Dec 29, 2007·International Journal of Pharmaceutics·A GiteauJ P Benoit
Jan 19, 2008·Nature Reviews. Genetics·Keith W Orford, David T Scadden
Jun 12, 2008·Tissue Engineering. Part C, Methods·Robert ChangWei Sun
Jun 17, 2008·Nature Methods·Kristin AlbertiPeter W Zandstra
Aug 12, 2008·Cell·In-Hyun ParkGeorge Q Daley
Aug 30, 2008·Current Opinion in Biotechnology·Shara M DellatoreWilliam M Miller
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·Elisabetta RoselliniPaolo Giusti
Dec 9, 2008·Cell Stem Cell·Lars Ahrlund-RichterMahendra Rao
Feb 11, 2009·Nature Reviews. Genetics·John F BatemanShireen R Lamandé
Apr 29, 2009·Cell Stem Cell·Hongyan ZhouSheng Ding
May 22, 2009·Nature Materials·Elsie S PlaceMolly M Stevens
Jul 10, 2009·Tissue Engineering. Part C, Methods·SangJun MoonUtkan Demirci
Aug 5, 2009·Biomaterials·David F Williams
Sep 25, 2009·Biomaterials·Nic D Leipzig, Molly S Shoichet
Oct 27, 2009·Developmental Biology·Tania Rozario, Douglas W DeSimone
Oct 28, 2009·Nature Reviews. Genetics·Juan Carlos Izpisúa BelmonteShinya Yamanaka

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Citations

Nov 11, 2016·Stem Cells International·Chang Youn LeeWoochul Chang
Nov 1, 2016·Biotechnology Journal·Ahmed Abdal DayemSsang-Goo Cho
Apr 8, 2017·Current Opinion in Biotechnology·Tina TronserPavel A Levkin
Nov 29, 2017·Cellular and Molecular Life Sciences : CMLS·Salamah M AlwahshDavid C Hay
Jun 22, 2017·Journal of Tissue Engineering and Regenerative Medicine·Fredrik E O HolmbergOle H Nielsen
Dec 9, 2017·Annual Review of Biomedical Engineering·Christopher M Madl, Sarah C Heilshorn
Apr 19, 2018·Frontiers in Pediatrics·Elizabeth A LaMarcaKristen J Brennand
Jul 1, 2020·Advanced Biosystems·David W GreenArtemis Stamboulis
Jan 2, 2019·Biomaterials Research·Seong Gyu KwonJae Ho Kim
May 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Giuliana E Salazar-NorattoRobert E Guldberg
Feb 27, 2016·Journal of Biomaterials Applications·Hossein BaniasadiYasamin Haghirsharifzamini
Mar 25, 2017·Acta Odontologica Scandinavica·Hyunmin ChoiYoung-Bum Park
Oct 3, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Joseph LongDeok-Ho Kim
Nov 25, 2019·Stem Cell Reviews and Reports·Gele LiuRichard G Fessler
Jul 18, 2017·Trends in Biotechnology·Amr A Abdeen, Krishanu Saha
Mar 23, 2021·Acta Biomaterialia·Sheng Yin, Yi Cao
Apr 6, 2021·Frontiers in Bioengineering and Biotechnology·Maria Grazia TuponeAnnamaria Cimini
Apr 27, 2021·Frontiers in Medicine·Donald R CampbellChelsea M Magin
Aug 2, 2021·Colloids and Surfaces. B, Biointerfaces·M R PoornaUllas Mony
Jul 9, 2018·ACS Biomaterials Science & Engineering·Kaiming YePeng Yin
Aug 30, 2017·ACS Nano·Dorothee WasserbergPascal Jonkheijm

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