Application of cancer-testis antigens in immunotherapy of hepatocellular carcinoma

Immunotherapy
Mahnaz Seifi-AlanSoudeh Ghafouri-Fard

Abstract

Hepatocellular carcinoma (HCC) is a worldwide common malignancy with poor prognosis. Several studies have aimed at identification of appropriate biomarkers for early detection of this cancer. Cancer-testis antigens (CTAs) as a novel group of tumor-associated antigens have been demonstrated to be expressed in HCC samples as well as peripheral blood samples from these patients but not in the corresponding adjacent noncancerous samples. Such pattern of expression has provided them an opportunity to be used as immunotherapeutic targets. The detection of spontaneous immune responses against CTAs in HCC patients has prompted design of CTA-based immunotherapeutic protocols in these patients. The results of some clinical trials have been promising in a subset of patients.

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Citations

Feb 10, 2019·The Journal of Pharmacology and Experimental Therapeutics·Bruna CorradettiMauro Ferrari
Jul 30, 2019·Human Antibodies·Sepideh Dashti, Zahra Taherian-Esfahani
Feb 1, 2020·Oncoimmunology·Peter G HendricksonGabriel C Fine
Mar 26, 2019·Human Antibodies·Zahra Taherian-Esfahani, Sepideh Dashti
Apr 23, 2019·Human Antibodies·Maliheh AstanehZahra Taherian Esfahani

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Methods Mentioned

BETA
surgical resection

Software Mentioned

GeneMANIA
DERMA

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