Application of chitin and chitosan as elicitors of coumarins and fluoroquinolone alkaloids in Ruta graveolens L. (common rue)

Biotechnology and Applied Biochemistry
Aleksandra OrlitaPiotr Stepnowski

Abstract

Common rue (Ruta graveolens L.) accumulates various types of secondary metabolites, such as coumarins furanocoumarins, acridone and quinolone alkaloids and flavonoids. Elicitation is a tool extensively used for enhancing secondary-metabolite yields. Chitin and chitosan are examples of elicitors inducing phytoalexin accumulation in plant tissue. The present paper describes the application of chitin and chitosan as potential elicitors of secondary-metabolite accumulation in R. graveolens shoots cultivated in vitro. The simple coumarins, linear furanocoumarins, dihydrofuranocoumarins and fluoroquinolone alkaloids biosynthesized in the presence of chitin and chitosan were isolated, separated and identified. There was a significant increase in the growth rate of R. graveolens shoots in the presence of either chitin or chitosan. Moreover, the results of the elicitation of coumarins and alkaloids accumulated by R. graveolens shoots in the presence of chitin and chitosan show that both compounds induced a significant increase in the concentrations of nearly all the metabolites. Adding 0.01% chitin caused the increase in the quantity (microg/g dry weight) of coumarins (pinnarin up to 116.7, rutacultin up to 287.0, bergapten up to 904.3,...Continue Reading

Citations

Sep 24, 2010·Applied Biochemistry and Biotechnology·Renuka Diwan, Nutan Malpathak
Jun 28, 2016·International Journal of Molecular Sciences·Massimo Malerba, Raffaella Cerana
Oct 13, 2016·BMC Complementary and Alternative Medicine·Jaime Stella Moses RichardsonSri Nurestri Abdul Malek
Apr 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Urszula ZłotekAnna Jakubczyk
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Apr 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wojciech MakowskiAleksandra Królicka
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Izabela PerkowskaAnna Ihnatowicz
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lutfun NaharSatyajit D Sarker

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