Application of chromosomal microarray analysis in products of miscarriage

Molecular Cytogenetics
Xiangyu ZhuYali Hu

Abstract

Chromosomal abnormality is one of the major cause of spontaneous abortion. Most available guidelines suggest genetic testing after three miscarriages, which has been proved to be difficult to adhere to and somewhat of low cost-effectiveness. As chromosomal microarray analysis has been recommended to be applied on miscarriage products, we managed a retrospective study on our experience investigate the potential impact of this technique on previous guidelines and our present management on miscarried couples and products. Of the 405 products of conceptions, the overall detection rate of pathogenetic results was 55.3% (224/405), including 7.1% (16/224) copy number changes which could be missed by conventional karyotyping analysis. Of the 222 natural conception samples, abnormal genetic results were found in 126 cases (56.8%). The detection rate in the assistant reproductive treatment group was 53.6% (98/183). No significant difference was found between these two groups (p = 0.645, OR = 1.110 with 95% CI: 0.713-1.726). The detection rate was 53.2% (75/141) in 141 product-of-conceptions (POCs) of mothers with adverse pregnancy histories. Of the 264 POC samples of mothers without abnormal pregnancy histories, 56.4% (149/264) were gene...Continue Reading

References

Oct 4, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN American College of Obstetricians and Gynecologists
Feb 18, 2004·Fertility and Sterility·Mayumi Sugiura-OgasawaraKaoru Suzumori
May 2, 2006·Obstetrics and Gynecology·Katherine BiancoMary E Norton
Feb 24, 2007·Human Reproduction·M T M FranssenM Goddijn
Sep 15, 2009·Fertility and Sterility·M Carmen MartínezJose Landeras
Nov 19, 2009·American Journal of Medical Genetics. Part a·Elizabeth De SouzaJoan K Morris
Mar 9, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sohinee BhattacharyaSiladitya Bhattacharya
Nov 4, 2010·BMC Medical Genetics·Ji Won KimSung Han Shim
Jan 19, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Emmy Van Den BoogaardMariëtte Goddijn
Jun 18, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Hutton M KearneyUNKNOWN Working Group of the American College of Medical Genetics Laboratory Quality Assurance Committee
Sep 1, 2001·Stress : the International Journal on the Biology of Stress·M Craig
Apr 24, 2012·Fertility and Sterility·Nasser Al-AsmarCarmen Rubio
Jun 13, 2012·Reproductive Biomedicine Online·W LiT C Li
Jul 17, 2012·Biochimica Et Biophysica Acta·Merel M J van den BergMariëtte Goddijn
Jan 31, 2013·Psychosomatic Medicine·Tamar WainstockEyal Y Anteby
Aug 24, 2013·Human Reproduction·E van den BoogaardM Goddijn
Apr 24, 2014·The Journal of Obstetrics and Gynaecology Research·Mayumi Sugiura-OgasawaraNobuhiro Suzumori
Jan 8, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·F P McCarthyK O'Donoghue
Mar 18, 2015·Journal of Assisted Reproduction and Genetics·Inmaculada Campos-GalindoCarmen Rubio
Apr 8, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J A RosenfeldD Chitayat

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Citations

Jun 27, 2020·Current Opinion in Obstetrics & Gynecology·Ralph S Papas, William H Kutteh
Nov 25, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Lingshan GouMaosheng Gu
May 1, 2021·Reproductive Biomedicine Online·Elias M Dahdouh, William H Kutteh
Jul 31, 2021·The Application of Clinical Genetics·Ralph S Papas, William H Kutteh

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Methods Mentioned

BETA
chips
PCR

Software Mentioned

SPSS Statistics
GW
APHx

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