Application of Constrained Optimization Methods in Health Services Research: Report 2 of the ISPOR Optimization Methods Emerging Good Practices Task Force

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
William CrownKalyan S Pasupathy

Abstract

Constrained optimization methods are already widely used in health care to solve problems that represent traditional applications of operations research methods, such as choosing the optimal location for new facilities or making the most efficient use of operating room capacity. In this paper we illustrate the potential utility of these methods for finding optimal solutions to problems in health care delivery and policy. To do so, we selected three award-winning papers in health care delivery or policy development, reflecting a range of optimization algorithms. Two of the three papers are reviewed using the ISPOR Constrained Optimization Good Practice Checklist, adapted from the framework presented in the initial Optimization Task Force Report. The first case study illustrates application of linear programming to determine the optimal mix of screening and vaccination strategies for the prevention of cervical cancer. The second case illustrates application of the Markov Decision Process to find the optimal strategy for treating type 2 diabetes patients for hypercholesterolemia using statins. The third paper (described in Appendix 1) is used as an educational tool. The goal is to describe the characteristics of a radiation therap...Continue Reading

Citations

Nov 23, 2019·Applied Health Economics and Health Policy·Baudouin StandaertPhilip O Buck
Mar 5, 2020·Journal of Market Access & Health Policy·Baudouin StandaertSharon Zhang
Sep 6, 2019·Computational and Mathematical Methods in Medicine·Giedrius VanagasKa Lok Man
Feb 9, 2020·Applied Health Economics and Health Policy·William H Crown
Feb 2, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Hendrik KoffijbergMarjolein J E Greuter
Feb 12, 2020·Value in Health Regional Issues·Lijoy VargheseBaudouin A Standaert
Apr 9, 2021·Journal of Market Access & Health Policy·Ru HanMondher Toumi
Apr 14, 2021·Value in Health Regional Issues·Jan OlbrechtBaudouin Standaert
Apr 30, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Martijn SimonsValesca Retèl
Jun 5, 2021·Journal of Biomedical Informatics·Michael KoNigam H Shah
Jun 25, 2021·Value in Health Regional Issues·César Augusto Guevara-CuellarPaola Martínez
Dec 24, 2020·Journal of the American Medical Informatics Association : JAMIA·Kenneth JungNigam H Shah
Aug 10, 2021·Journal of Market Access & Health Policy·Christophe SauboinBaudouin Standaert
Aug 11, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Yunxiang Bai, Bjorn P Berg
Oct 14, 2018·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Josephine MauskopfJohan L Severens
Nov 9, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Chun-Yi LuYu-Fan Ho

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