Application of Cu-64 NODAGA-PSMA PET in Prostate Cancer.

Advances in Therapy
Sabina SevcencoSiroos Mirzaei

Abstract

The high diagnostic potential of 64Cu-PSMA PET-CT imaging was clinically investigated in prostate cancer patients with recurrent disease and in the primary staging of selected patients with advanced local disease. The aim of our study is to assess the uptake behavior in the clinical setting of 64Copper Prostate-Specific Membrane Antigen (64Cu PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) in prostate cancer. A retrospective study was performed in 23 patients with intermediate, high risk and progressive disease at primary staging of prostate cancer. All patients underwent 64Cu-PSMA PET. Overall, 250 MBq (4 MBq per kg bodyweight, range 230-290 MBq) of 64Cu-NODAGA PSMA was intravenously applied. PET images were performed 30 min (pelvis and abdomen) and 1-2 h post-injection (skull base to mid-thigh). Maximum standardized uptake values (SUVmax) were measured in the organs with high physiological uptake such as liver and kidney, and, additionally, background activity was measured in the gluteal area and in suspected tumor lesions using a HERMES workstation. PSMA uptake was detected in prostate bed in nine patients, in six patients in distant metastases (bone, lung and liver) and in nine patients in lymph nodes. Of 23...Continue Reading

References

Jul 28, 2013·Current Radiopharmaceuticals·Laura EvangelistaGiuseppe Lucio Cascini
Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Nov 21, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
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Oct 8, 2016·Cancer Biotherapy & Radiopharmaceuticals·Bernhard GrubmüllerSiroos Mirzaei

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Citations

Feb 6, 2020·Pharmaceuticals·Christine Rangger, Roland Haubner
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro Amor-CoarasaJohn W Babich
Jul 24, 2020·Oncology and Therapy·Siroos MirzaeiAbass Alavi
Sep 10, 2020·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Arnoldo PiccardoLaura Evangelista
Oct 14, 2020·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Siroos Mirzaei, Rainer W Lipp
Sep 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·José Carlos Dos SantosWalter Mier
Jun 12, 2021·Clinical Nuclear Medicine·David R Cardoza-Ochoa, Belén Rivera-Bravo

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