Application of cytogenetics in neoplastic diseases

This review will concern itself with the application of cytogenetic findings in neoplastic diseases. This application can be divided into two general categories: practical and theoretical. The practical applications reside in utilizing karyotypic changes, particularly in leukemias and lymphomas, not only for diagnostic purposes but also for predicting response to therapy and prognosis. This is especially evident in the various acute nonlymphocytic leukemias and in most of the acute lymphoblastic leukemias. Thus, a definite correlation exists between the cytogenetic findings and the various clinical, laboratory, and cytologic parameters of most of the leukemias. Undoubtedly, these leukemias will ultimately be classified and defined more in terms of their cytogenetic aspects than any other. Though the application in lymphoma is not at the same level as that in leukemia, developments in that field certainly indicate a similar utilization of the cytogenetic findings in these diseases. The presence or absence of a Ph1 chromosome in a chronic myelocytic leukemia has been utilized widely, not only in the diagnosis but also in the predictability of response; the cytogenetic findings have also been utilized in predicting the blastic pha...Continue Reading